Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802469 | PMC |
| http://dx.doi.org/10.1093/gpbjnl/qzae090 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dissecting the Molecular Determinants of α-synuclein Phase Separation and Condensate Aging: The Pivotal Role of β-Sheet-Rich Motifs.
Adv Sci (Weinh)
September 2025
Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Science (Ministry of Education), Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200433, China.
Emerging evidence indicates that liquid-liquid phase separation of α-synuclein occurs during the nucleation step of its aggregation, a pivotal step in the onset of Parkinson's disease. Elucidating the molecular determinants governing this process is essential for understanding the pathological mechanisms of diseases and developing therapeutic strategies that target early-stage aggregation. While previous studies have identified residues critical for α-synuclein amyloid formation, the key residues and molecular drivers of its phase separation remain largely unexplored.
View Article and Find Full Text PDFMacrophage cannibalism: efferocytosis in atherosclerosis.
Curr Opin Lipidol
August 2025
Cardiometabolic Immunity Laboratory, Department of Physiology, Monash Biomedicine Discovery Institute (BDI) and Victorian Heart Institute (VHI), Monash University, Melbourne, Victoria, Australia.
Purpose Of Review: This review explores the evolving understanding of efferocytosis - the clearance of dead or dying cells by phagocytes - in the context of atherosclerosis. It highlights recent discovers in cell death modalities, impaired clearance mechanisms and emerging therapeutic strategies aimed at restoring efferocytosis to stabilize plaques and resolve inflammation.
Recent Findings: Recent studies have expanded the scope of efferocytosis beyond apoptotic cells to include other pro-inflammatory cell death modes, including pyroptosis, necroptosis and ferroptosis, revealing context-dependent clearance efficiency and immunological outcomes.
Tailoring butane-1,2,3,4-tetraol-based maltosides (BTMs) group-swapping and detergent unsymmetry: new detergent design strategies for membrane protein studies.
J Mater Chem B
September 2025
Major in Bionano Engineering, School of Bio-Pharmaceutical Convergence, Hanyang University, Ansan, 155-88, Republic of Korea.
Membrane proteins are essential bio-macromolecules involved in numerous critical biological processes and serve as therapeutic targets for a wide range of modern pharmaceuticals. Small amphipathic molecules, called detergents or surfactants, are widely used for the isolation and structural characterization of these proteins. A key requirement for such studies is their ability to maintain membrane protein stability in aqueous solution, a task where conventional detergents often fall short.
View Article and Find Full Text PDFMigrasomes in Health and Disease: Insights into Mechanisms, Pathogenesis, and Therapeutic Opportunities.
Cell Physiol Biochem
September 2025
Department of Histology and Embryology and Vascular Biology Student Research Club, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland, E-Mail:
Migrasomes are newly discovered, migration-dependent organelles that mediate the release of cellular contents into the extracellular environment through a process known as migracytosis. Since their identification in 2014, growing evidence has highlighted their critical roles in intercellular communication, organ development, mitochondrial quality control, and disease pathogenesis. Migrasome biogenesis is a complex, multi-step process tightly regulated by lipid composition, tetraspanin-enriched microdomains, and molecular pathways involving sphingomyelin synthase 2, Rab35, and integrins.
View Article and Find Full Text PDFBelief in a Just World Promotes Youth Intergenerational Altruism by Increasing Subjective Well-Being: Authenticity Makes a Difference.
Scand J Psychol
September 2025
School of Psychology, Shanghai Normal University, Shanghai, China.
Promoting intergenerational altruism among the current youth generation is crucial, and belief in a just world (BJW) may be a protective factor for intergenerational altruism. Inspired by the broaden-and-build theory of positive emotion, our research aims to investigate the relationship between BJW and intergenerational altruism among youths as well as to explore the mediating role of subjective well-being and the moderating role of authenticity in the focal relationship. Three empirical sub-studies with cross-sectional, experimental, and longitudinal designs were performed.
View Article and Find Full Text PDF