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Antipsychotic polypharmacy in patients with schizophrenia between 1999 and 2024 in Denmark: Prevalence, time trends, and combinations.
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Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.
Antipsychotic polypharmacy (APP) remains common in the treatment of schizophrenia despite increased risk of adverse events and limited evidence of additional efficacy compared to antipsychotic monotherapy (APM). We conducted a nationwide, register-based cohort study to characterize APP among patients with schizophrenia in Denmark, 1997-2021. Patients were followed from year 3 after the schizophrenia diagnosis and onwards.
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Institute of Pharmaceutical Sciences, Kings College London, WC2R 2LS, UK; North East London NHS Foundation Trust, IG3 8YY, UK.
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View Article and Find Full Text PDFDiscontinuing Chronic Medications Suggested for Deprescribing in Routine Clinical Practice: Nationwide Evidence From Routinely Collected Data in Swedish Older Adults.
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Cost trends of potentially inappropriate medications among older adults between 2012 and 2021 in Quebec, Canada: a population-based repeated cross-sectional study.
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Faculté de pharmacie, Université Laval, Québec, Québec, Canada.
Background: Potentially inappropriate medications (PIMs) are frequent in older adults, contributing to hospitalizations, adverse events, and healthcare burden. We aimed to estimate direct PIM cost trends from 2012 to 2021 among older women and men in Quebec, Canada.
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Pattern and Associated Factors of Benzodiazepine Discontinuation Among Older Adults Following Hospitalization.
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Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Background: Prolonged benzodiazepine (BZD) use following hospital discharge may heighten the risk of BZD dependence and serious adverse drug events in older adults. However, there is limited understanding of BZD discontinuation pattern and associated factors in this population.
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