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Polypharmacy in managing severe tuberculosis patients usually poses a risk of adverse drug reactions. Contezolid is a new oxazolidinone antibiotic showing good in vitro and in vivo activity against . Contezolid add-on regimen shows promising efficacy and safety results in managing severe tuberculosis patients complicated with acute thrombocytopenia.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655174 | PMC |
http://dx.doi.org/10.1002/ccr3.70001 | DOI Listing |
Med Trop Sante Int
July 2025
Unité des maladies infectieuses et tropicales et CIC Inserm 1424, Centre hospitalier de Cayenne, Cayenne, Guyane.
Tahiti or the "myth of Paradise", Bora Bora, "the Pearl of the Pacific". Who has never wanted to take a plane and come and land on the heavenly beaches of Polynesia, a French territory at the antipodes of mainland France lost in the middle of the Pacific? However, we do not imagine that 60% of Polynesians live below the metropolitan low-income threshold or that life expectancy is lower than that of the mainland due to the high prevalence of cardiovascular diseases with three quarters overweight population.In addition to non-transmissible metabolic diseases, various pathologies common to temperate countries present specificities in Polynesia, leading to sometimes different management and medical reasoning.
View Article and Find Full Text PDFFront Psychiatry
August 2025
Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Introduction: Anxiety, depression, and insomnia are common among older patients with tuberculosis (TB), yet their associations with inflammatory responses and drug-induced liver injury (DILI) remain insufficiently explored. This study aimed to identify distinct inflammation-DILI phenotypes in older TB patients and examine differences in anxiety, depression, and insomnia across subgroups.
Methods: In this cross-sectional study, 251 older TB patients were evaluated.
Int J Infect Dis
September 2025
SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontei
Background: Mycobacterium simiae is a slow-growing environmental nontuberculous mycobacterium (NTM), commonly isolated from soil and water. M. simiae is not known to transmit zoonotically or via human-to-human contact; infection is presumed to occur through direct environmental exposure.
View Article and Find Full Text PDFPLoS Biol
September 2025
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.
Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB disease that occur in humans and allows identification of genomic loci underlying clinical outcomes. We previously mapped a TB susceptibility locus on mouse chromosome 2.
View Article and Find Full Text PDFJAAPA
September 2025
Clay W. Walker is an assistant professor of family medicine at Mayo Clinic in Phoenix, AZ; director of didactic education and an assistant professor in the PA program at A.T. Still University in Mesa, AZ; and an adjunct assistant professor at Rush University in Chicago, IL. Thomas Hartman is directo
Hemoptysis, defined as the expectoration of blood originating from the lower respiratory tract, is a clinical symptom with a wide differential diagnosis that ranges from benign to life-threatening causes. Common causes vary by geographic region and care setting, with respiratory infections, malignancy, bronchiectasis, and chronic obstructive pulmonary disease being predominant in resource-rich countries and tuberculosis remaining the leading cause in resource-limited areas. Though most cases are mild and self-limited, hemoptysis can be a life-threatening medical emergency; these cases are associated with a mortality exceeding 50%, primarily due to asphyxia.
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