Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: Mid-regional pro-adrenomedullin (MR-proADM) and monocyte CD169 (CD169) are valuable prognostic indicators of severe COVID-19.
Methods: We assessed the predictive ability of a single measurement of MR-proADM and CD169 at emergency department (ED) admission to forecast in-hospital and 60-day mortality in adult COVID-19 patients. We analyzed clinical and laboratory data, with in-hospital mortality as the primary endpoint and 60-day mortality as the secondary endpoint. We examined associations with clinical and laboratory variables through univariate and multivariate analyses.
Results: Data from 382 patients over 14 months were analyzed. Significant predictors of in-hospital mortality included age ⩾ 70 years (hazard ratio [HR] 8.1; 95% confidence interval [CI] 2.2-29.5), CD169 ratio ⩾ 20 (HR: 2.4; 95%CI: 1.6-5.6), MR-proADM ⩾ 1.1 mmol/L (HR: 5.1; 95%CI: 1.7-15.6), the need for invasive mechanical ventilation (HR: 6.8; 95%CI: 2.4-19.1), and active cancer (HR: 5.2; 95%CI: 1.8-15.2). For 60-day mortality, only elevated MR-proADM levels showed predictive value (HR: 6.7; 95%CI: 1.7-25.0), while high serologic titer was protective (HR: 0.4; 95%CI: 0.1-0.9).
Conclusion: A single MR-proADM and CD169 measurement upon ED admission has prognostic value for in-hospital mortality, with MR-proADM also predicting 60-day mortality.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650471 | PMC |
| http://dx.doi.org/10.1177/2632010X241304958 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Persistent inpatient delirium associated with increased length of stay and mortality.
PLoS One
September 2025
Department of Family and Community Medicine, University of Louisville, Owensboro, Kentucky, United States of America.
Introduction: Delirium is associated with an increased risk of post-hospitalization mortality. However, the impact of persistent delirium on mortality is not well defined.
Methods: We conducted a retrospective cohort study on the association of non-persistent or persistent delirium and mortality.
Time series analysis between platelet counts and 60-day mortality in sepsis patients with thrombocytopenia: a retrospective cohort study.
BMC Infect Dis
September 2025
Department of Blood Transfusion, Chengdu Second People's Hospital, No 10 Qingyun South Street, Chengdu, Sichuan, 610036, China.
Background: Thrombocytopenia is a prevalent complication and an adverse prognostic factor in sepsis; however, there is a paucity of studies examining the dynamic changes in platelet counts and their association with the prognosis of sepsis patients with related thrombocytopenia. This study aims to retrospectively to investigate the relationship between the dynamic trajectories of platelet counts and early adverse prognostic outcomes in such patients.
Methods: A retrospective observational study was conducted using data from 946 sepsis patients with thrombocytopenia extracted from the Medical Information Mart for Intensive Care (MIMIC-IV) database.
Safety and efficacy of semi-dose venetoclax plus azacitidine in unfit acute myeloid leukemia patients in China: a real-world single-center study.
Invest New Drugs
September 2025
Department of Hematology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Acute myeloid leukemia (AML) carries a poor prognosis in elderly or medically unfit patients, with median overall survival (OS) of only 7-8 months for those ineligible for intensive chemotherapy. While venetoclax (VEN) combined with azacitidine (AZA) has become a standard therapy, real-world evidence indicates that Asian patients experience higher VEN exposure and toxicity with the standard 400 mg/day dose. This retrospective study aimed to evaluate the efficacy and safety of a reduced-dose regimen (VEN 200 mg/day + AZA) in frail/elderly Chinese AML patients deemed unfit for intensive therapy.
View Article and Find Full Text PDFEffect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.
Pancreatology
August 2025
Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. Electronic address: xiali
Background: Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis.
Methods: In this single-center trial, we randomly assigned 60 patients with acute pancreatitis in the intensive care unit (ICU) to receive 5 % albumin and crystalloid solution or crystalloid solution alone. Patients in the albumin group received 30 g of 5 % albumin daily within the first 3 days of admission.
Impact of early enteral nutrition on the prognosis of mechanically ventilated patients with chronic obstructive pulmonary disease: a retrospective cohort study based on the MIMIC-IV Database.
Front Nutr
August 2025
Department of Critical Care Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, China.
Background: While early enteral nutrition (EN) is recommended for critically ill patients, its specific impact on mechanically ventilated chronic obstructive pulmonary disease (COPD) patients remains uncertain.
Methods: We analyzed data extracted from the MIMIC-IV 3.0 database, focusing on patients with COPD who received invasive mechanical ventilation.