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Lumbar spinal stenosis (LSS) is a major cause of chronic lower back and leg pain, and is traditionally diagnosed through labor-intensive analysis of magnetic resonance imaging (MRI) scans by radiologists. This study aims to streamline the diagnostic process by developing an automated radiology report generation (ARRG) system using a vision-language (VL) model. We utilized a Generative Image-to-Text (GIT) model, originally designed for visual question answering (VQA) and image captioning. The model was fine-tuned to generate diagnostic reports directly from lumbar spine MRI scans using a modest set of annotated data. Additionally, GPT-4 was used to convert semistructured text into coherent paragraphs for better comprehension by the GIT model. The model effectively generated semantically accurate and grammatically coherent reports. The performance was evaluated using METEOR (0.37), BERTScore (0.886), and ROUGE-L (0.3), indicating its potential to produce clinically relevant content. This study highlights the feasibility of using vision-language models to automate report generation from medical imaging, potentially reducing the diagnostic workload for radiologists.
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http://dx.doi.org/10.3390/jcm13237092 | DOI Listing |
Comput Biol Med
September 2025
INSIGNEO Institute for in silico medicine, University of Sheffield, UK; School of Mechanical, Aerospace and Civil Engineering, University of Sheffield, UK. Electronic address:
Modelling cardiovascular disease is at the forefront of efforts to use computational tools to assist in the analysis and forecasting of an individual's state of health. To build trust in such tools, it is crucial to understand how different approaches perform when applied to a nominally identical scenario, both singularly and across a population. To examine such differences, we have studied the flow in aneurysms located on the internal carotid artery and middle cerebral artery using the commercial solver Ansys CFX and the open-source code HemeLB.
View Article and Find Full Text PDFStem Cell Res
September 2025
Department of General Pediatrics, Neonatology, and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf 40225, Germany. Electronic address:
Pathogenic variants in the gene COQ4 cause primary coenzyme Q deficiency, which is associated with symptoms ranging from early epileptic encephalopathy up to adult-onset ataxia-spasticity spectrum disease. We genetically modified commercially available wild-type iPS cells by using a CRISPR/Cas9 approach to create heterozygous and homozygous isogenic cell lines carrying the disease-causing COQ4 variants c.458C > T, p.
View Article and Find Full Text PDFPathol Res Pract
September 2025
Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China. Electronic address:
Background: Dermal clear cell sarcoma (DCCS) is a rare malignant mesenchymal neoplasm. Owing to the overlaps in its morphological and immunophenotypic profiles with a broad spectrum of tumors exhibiting melanocytic differentiation, it is frequently misdiagnosed as other tumor entities in clinical practice. By systematically analyzing the clinicopathological characteristics, immunophenotypic features, and molecular biological properties of DCCS, this study intends to further enhance pathologists' understanding of this disease and provide a valuable reference for its accurate diagnosis.
View Article and Find Full Text PDFArch Med Res
September 2025
Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan. Electronic address:
Background: Atherosclerosis, a leading cause of cardiovascular disease (CVD) mortality worldwide, is characterized by dysregulated lipid metabolism and unresolved inflammation. Macrophage-derived foam cell formation and apoptosis contribute to plaque formation and vulnerability. Elevated serum galectin-3 (Gal-3) levels are associated with increased CVD risk, and Gal-3 in plaques is strongly associated with macrophages.
View Article and Find Full Text PDFBiomacromolecules
September 2025
Department of Chemistry, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
Marine biofouling poses significant economic and environmental challenges, highlighting the need for effective antifouling coatings. We report amphiphilic poly(SBMA--EGDEA) copolymer coatings that resist both marine diatom adhesion and sediment adsorption. The coatings were synthesized via surface-initiated ATRP and RAFT polymerization using hydrophilic sulfobetaine methacrylate (SBMA) and hydrophobic ethylene glycol dicyclopentenyl ether acrylate (EGDEA).
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