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Intravenous (IV) magnesium sulfate, a versatile electrolyte, plays a pivotal role across various medical domains. From cardiac care to obstetrics, gastrointestinal to pulmonary therapies, the impact is far-reaching among acute care services. Notably, in the postoperative phase of care, it shares intriguing similarities with ketamine as an NMDA receptor antagonist. This case series describes the difficulties experienced with postoperative analgesia in three patient cases with complex comorbidities and discusses the beneficial impact observed when magnesium was administered concomitantly with ketamine. Further research is necessary to outline the specific role, ideal population, and recommended bolus and infusion rate for optimal analgesic efficacy.
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http://dx.doi.org/10.1080/15360288.2024.2441794 | DOI Listing |
Cureus
August 2025
Department of Anesthesiology and Critical Care, GSVM (Ganesh Shankar Vidyarthi Memorial) Medical College, Kanpur, IND.
Introduction: The goal of perioperative management in reactive airway disease (RAD) patients is to ensure optimal airway stability, maintain adequate oxygenation, and reduce the need for mechanical ventilation while minimizing airway irritation and inflammation. Due to the airway hyperresponsiveness and increased risk of respiratory complications in RAD patients, non-opioid adjuncts that provide both bronchodilation and analgesia are preferred. Lignocaine and magnesium sulfate (MgSO₄) have emerged as effective agents in this context.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, Jilin Province, China.
Rationale: Gitelman syndrome, also known as familial hypokalemia, is primarily characterized by hypokalemic metabolic alkalosis, severe hypomagnesemia, and hypocalciuria.
Patient Concerns: A 26-year-old female patient presented with a 4-month history of amenorrhea, intermittent nausea and vomiting for 1.5 months, and worsening symptoms in the past day.
Cureus
July 2025
General Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, GBR.
Introduction Magnesium is essential for regulating cardiovascular, neuromuscular, and respiratory functions. Hypomagnesemia in older adults is often overlooked and insufficiently managed. Inadequate monitoring and correction of hypomagnesemia may leave old and frail patients more vulnerable to acute cognitive decline, which in some cases can be preventable.
View Article and Find Full Text PDFNeurosci Bull
August 2025
School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Cerebral edema is characterized by fluid accumulation, and the glymphatic system (GS) plays a pivotal role in regulating fluid transport. Using the Tenecteplase system, magnesium salt of salvianolic acid B/ginsenoside Rg1 (SalB/Rg1) was injected intravenously into mice 4.5 h after middle cerebral artery occlusion and once every 24 h for the following 72 h.
View Article and Find Full Text PDFJ Pharm Technol
August 2025
North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.
Refeeding syndrome (RS) is a potentially life-threatening condition, marked by decreases in serum phosphorus, potassium, or magnesium, that commonly occurs in patients who receive parenteral nutrition (PN) after a period of inadequate caloric intake. To compare the occurrence and severity of RS in hospitalized patients who received intravenous (IV) electrolyte supplementation versus those who did not receive IV electrolyte supplementation prior to initiation of PN. This single-center, retrospective cohort study included adult patients hospitalized over a 10-year period who received PN.
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