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http://dx.doi.org/10.4088/PCC.24cr03731 | DOI Listing |
Cureus
June 2025
Osteopathic Medicine/Family Medicine, Lake Erie College of Osteopathic Medicine, Elmira, USA.
Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonin activity in the central and peripheral nervous systems that can lead to symptoms such as altered mental status, autonomic instability (e.g., hyperthermia and hypertensive tachycardia), and neuromuscular abnormalities (e.
View Article and Find Full Text PDFInt J Mol Sci
June 2025
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Influenza is still a chronic global health threat, inducing a sustained search for effective antiviral therapeutics. Computational methods have played a pivotal role in developing small molecule therapeutics. In this study, we applied a combined in silico and in vitro approach to explore the potential anti-influenza activity of cyproheptadine, a clinically used histamine H1 receptor antagonist.
View Article and Find Full Text PDFPediatr Neurol
September 2025
Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark; Department of Epilepsy Genetics and Personalized Medicine, Danish Epilepsy Centre, Dianalund, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Member of ERN EpiCARE. Electronic
Background: Haploinsufficiency of the bromodomain PHD finger transcription factor (BPTF) gene, essential in chromatin remodeling, leads to a neurodevelopmental disorder characterized by dysmorphic facies, distal limb anomalies, neurological disturbances, epilepsy, and gastrointestinal symptoms.
Methods: Families with BPTF-related neurodevelopmental disorders, with or without gastrointestinal symptoms, were recruited through an international collaboration. Data were collected via questionnaires on demographics, clinical features, genetics, and comorbidities, focusing on cyclical vomiting syndrome (CVS).
Front Immunol
June 2025
Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, China.
Objective: This study seeks to assess the effectiveness and safety of a combination treatment involving loratadine and mometasone furoate for patients suffering from allergic rhinitis (AR). Additionally, it explores the risk factors contributing to treatment failure, providing a theoretical basis for identifying safer and more effective AR treatments.
Methods: A prospective study was carried out between January 1, 2021, and April 1, 2023, involving 116 patients with allergic rhinitis (AR) who were treated at our outpatient clinic.
Cureus
May 2025
Department of Pharmacy, University of North Carolina (UNC) Health, Chapel Hill, USA.
Kava ( ) is consumed for a variety of medical and cultural purposes. It is reported to have anxiolytic, muscle relaxant, local anesthetic, and sedative properties. The unregulated use of kava has grown more popular in the United States for a variety of indications and often in combination with traditional pharmaceuticals.
View Article and Find Full Text PDF