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Background: A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor.
Summary: This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma. Optimal surgical sampling techniques for each lesion are presented.
Key Messages: In summary, the clinical and histopathologic features of several common and rare nail unit tumors and the optimal sampling techniques for each lesion are presented in this manuscript. Knowledge of the clinical and histopathologic features of these tumors informs the surgical approach to them and will produce the best patient outcomes.
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http://dx.doi.org/10.1159/000539383 | DOI Listing |
Dermatol Ther (Heidelb)
September 2025
Dermatology Clinic, University Hospital Company Polyclinic "G. Rodolico, San Marco", Catania, Italy.
Introduction: Psoriasis (PsO) is a common inflammatory dermatological condition with a substantial negative impact on patient quality of life. Several biological agents are available for the treatment of PsO, and clinicians and patients must consider various factors when deciding on the most appropriate biological agent.
Methods: Here, we report a set of consensus statements developed by an Italian PsO advisory board on use of the anti-interleukin-17A biological secukinumab in routine clinical practice.
RMD Open
August 2025
Department of Rheumatology and Clinical Immunology, Charite-Universitatsmedizin Berlin, Berlin, BE, Germany.
Background: Accurate and rapid diagnosis of rheumatic diseases is essential for further treatment decision. Different rheumatic diseases present characteristic patterns (image features) in fluorescence optical imaging (FOI). We developed an atlas of FOI image features and tested its ability to differentiate various rheumatic diseases.
View Article and Find Full Text PDFBone Joint J
September 2025
Oxford Trauma and Emergency Care, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kadoorie Research Centre, University of Oxford, Oxford, UK.
Aims: Mortality after a hip fracture has declined in recent years, but the risk of complications remains high. The aim of this study was to identify non-modifiable and, specifically, modifiable factors associated with the development of complications after hip fracture.
Methods: This was a multicentre, prospective cohort study of adults aged ≥ 60 years with a hip fracture who were treated in 77 hospitals in England, Wales, and Northern Ireland between July 2014 and November 2021.
Gels
August 2025
Department of Analytical Chemistry, Hamidiye Faculty of Pharmacy, University of Health Sciences, 34688 İstanbul, Turkey.
Ehrh. (great horsetail) belongs to the Equisetaceae family and its aerial parts have been traditionally used for skin conditions and to achieve healthy and resilient skin, nails, and hair. This study aimed to evaluate the inhibition of skin-related enzymes by, the antioxidant capacity of, and the phytochemical composition of .
View Article and Find Full Text PDFMicrobiol Spectr
August 2025
Department of Dermatology, Oulu University Hospital, Finland and Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Unlabelled: Superficial fungal infections in children are less prevalent compared with adults, and there are limited data on epidemiology in Northern Europe. This study retrospectively observed the epidemiological factors and treatment patterns of these infections in children in Northern Finland between 2000 and 2021. Patients under 18 years diagnosed with superficial tinea infections at the dermatology outpatient clinic of Oulu University Hospital were included in the study.
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