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Myocardial cGMP-PKG1α dysregulation contributes to ventricular tachycardia pathogenesis in type II diabetes and metabolic syndrome.
Heart Rhythm
August 2025
Molecular Cardiology Research Institute, Tufts Medical Center; Tufts University School of Medicine, Boston, MA; Tufts Medical Center, Department of Medicine; Division of Cardiology, Department of Medicine, Tufts Medical Center. Electronic address:
Background: Type-II diabetes (DMII) and metabolic syndrome (MBS) increase ventricular arrhythmia and sudden cardiac death risk.
Objectives: Identify mechanisms through which DMII and MBS promote ventricular tachycardia (VT).
Methods: We performed programmed ventricular stimulation (PVS) on leptin receptor mutant (Db/Db) mice with DMII, high fat high sucrose (HFHS)-fed mice with MBS, and cGMP-dependent Protein Kinase 1α (PKG1α) leucine zipper mutant (LZM) mice, which have neither DMII nor MBS but have disrupted PKG1α signaling.
Background: Type-II diabetes (DMII) and metabolic syndrome increase ventricular arrhythmia and sudden cardiac death risk.
Objectives: To identify signaling mechanisms through which DMII and metabolic syndrome promote ventricular tachycardia (VT).
Methods: We performed ventricular programmed stimulation on leptin receptor mutant (Db/Db) mice with DMII, high fat high sucrose (HFHS)-fed mice with metabolic syndrome, and cGMP-dependent Protein Kinase 1α (PKG1α) leucine zipper mutant (LZM) mice, which do not have DMII or metabolic syndrome but have disrupted PKG1α signaling.
Randomized Trial of Dietary Acid Reduction and Acid-Base Status of Patients With CKD and Normal Estimated GFR.
Kidney Int Rep
February 2025
Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA.
Introduction: Modern acid-producing diets in patients with stage G3 to G5 chronic kidney disease (CKD) can cause severe acid accumulation with metabolic acidosis and less severe accumulation causing eubicarbonatemic acidosis in stages G2 to G3, each with kidney injury. The impact of these diets on acid accumulation in those with CKD but normal estimated glomerular filtration rate (eGFR) (CKD G1) is unclear.
Methods: We assessed whether acid accumulation occurs in patients with CKD and normal eGFR, and if added base-producing fruits and vegetables (F&Vs) or oral sodium bicarbonate (NaHCO) (HCO ) reduces acid accumulation and/or lowers kidney injury.
Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.
Nat Genet
March 2025
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality with both monogenic and polygenic components. Here, we report results from a large genome-wide association study and multitrait analysis including 5,900 HCM cases, 68,359 controls and 36,083 UK Biobank participants with cardiac magnetic resonance imaging. We identified 70 loci (50 novel) associated with HCM and 62 loci (20 novel) associated with relevant left ventricular traits.
View Article and Find Full Text PDFResponse to Madias Je "can currently available data on takotsubo syndrome therapies guide us to manage future cases?
Am Heart J
February 2025
Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy. Electronic address: