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http://dx.doi.org/10.5826/dpc.1404a263 | DOI Listing |
Clin Exp Ophthalmol
August 2025
Department of Ophthalmology and Microtechnology, Yokohama City University Medical Centre, Yokohama, Japan.
Background: Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site. We investigate the role of microneedles with internal diameters as small as 49G for intraocular biopsy in the posterior and anterior segments.
Methods: Human uveal melanoma (UM 92-1) and retinoblastoma (Y79) cancer cell lines were aspirated using microneedles of different sizes with a vitrectomy set up, and cell viability was analysed.
Breast Cancer Res Treat
October 2025
Department of Surgery, Center for Breast Cancer, National Cancer Center, Goyang, South Korea.
Purpose: Ductal carcinoma in situ (DCIS) is a non-invasive breast cancer with variable risk of upstaging to invasive carcinoma. Accurate preoperative risk stratification is critical to guide management decisions and minimize overtreatment. This study aimed to identify clinicopathological and imaging predictors of DCIS upstaging to invasive cancer.
View Article and Find Full Text PDFPathobiology
July 2025
Department of Pathology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Introduction: Around 25% of patients with a biopsy diagnosis of pure ductal carcinoma in situ (DCIS) will be upstaged to invasive breast carcinoma (IBC) after surgery. Because of this upstaging risk, patients with high grade DCIS frequently undergo a sentinel lymph node procedure (SLNP), which can cause surgery-induced morbidity. Presentation with a palpable mass increases the upstaging risk, but histopathological predictors are currently unclear.
View Article and Find Full Text PDFDermatol Pract Concept
October 2024
Melanoma and Skin Cancer Unit, Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Histopathology
May 2024
Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Aims: Risk stratification of atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), diagnosed using breast biopsy, has great clinical significance. Clinical trials are currently exploring the possibility of active surveillance for low-risk lesions, whereas axillary lymph node staging may be considered during surgical planning for high-risk lesions. We aimed to develop a machine-learning algorithm based on whole-slide images of breast biopsy specimens and clinical information to predict the risk of upstaging to invasive breast cancer after wide excision.
View Article and Find Full Text PDF