Early-Stage Melanoma Benchmark Dataset.

Background: The early detection of melanoma is crucial for improving patient outcomes, as survival rates decline dramatically with disease progression. Despite significant achievements in deep learning methods for skin lesion analysis, several challenges limit their effectiveness in clinical practice. One of the key issues is the lack of knowledge about the melanoma stage distribution in the training data, raising concerns about the ability of these models to detect early-stage melanoma accurately.

Multimodal Imaging Detection of Difficult Mammary Paget Disease: Dermoscopy, Reflectance Confocal Microscopy, and Line-Field Confocal-Optical Coherence Tomography.

Mammary Paget disease (MPD) is a rare cutaneous malignancy associated with underlying ductal carcinoma in situ (DCIS) or invasive ductal carcinoma (IDC). Clinically, it appears as eczematous changes in the nipple and areola complex (NAC), which may include itching, redness, crusting, and ulceration; these symptoms can sometimes mimic benign dermatologic conditions such as nipple eczema, making early diagnosis challenging. A 56-year-old woman presented with persistent erythema and scaling of the left nipple, which did not respond to conventional dermatologic treatments: a high degree of suspicion prompted further investigation.

Dermoscopic Image Digital Post-Processing Perception and Use Among Members of the International Dermoscopy Society: Results of a Web-based Survey.

Introduction: Speculatively, digital image post-processing (DIPP) enhances diagnostic accuracy in dermoscopy.

Objective: We aimed to investigate the advantages and limitations of DIPP, as well as its perceived reliability and safety.

Methods: In this study we investigated the perception and use of DIPP among members of the International Dermoscopy Society through a web-based survey with 17 questions focusing on: (i) demographics (sex, age, nationality, specialty, professional experience in dermoscopy), (ii) application of digital dermoscopy, (iii) imaging devices, (iv) DIPP software usage, (v) area of DIPP application (e.

FDA and EMA-approved noninvasive imaging techniques for basal cell carcinoma subtyping: A systematic review.

Background: Basal cell carcinoma (BCC), the most common skin cancer, requires accurate subtyping for optimal treatment. While histopathology is the gold standard, noninvasive imaging offers a biopsy-free alternative, though its accuracy remains unclear.

Objective: To assess the diagnostic accuracy of Food and Drug Administration- and European Medicines Agency-approved noninvasive imaging techniques for BCC subtyping.

How to recognize a difficult squamous cell carcinoma? A retrospective analysis of clinically and dermatoscopically misdiagnosed tumors.

Background: Squamous cell carcinoma (SCC) is usually non-pigmented in fair-skinned individuals and has to be discriminated from other non-pigmented tumors. Although the dermatoscopic features of SCC are well-known, some SCCs are challenging to recognize even with dermatoscopy.

Objectives: To investigate clinical and dermatoscopic features responsible for an inaccurate clinical diagnosis of invasive SCC and potential clues that could help in their recognition.

Decision support system based on pattern detection in iterative dermoscopic screening.

Background And Objective: Videodermoscopy is the gold standard in melanoma diagnosis. A new research trend aims to support specialists' work by automating this examination method, but most research focuses on developing detectors to replace dermatologists. Our study aims to present a novel idea which focuses on supporting the examination process instead of completely automating it.

Ultraviolet-induced Fluorescence Patterns in Psoriasis: Insights from a Large International Cohort Study.

Introduction: Psoriasis is a common skin disease displaying a broad spectrum of clinical presentations that can sometimes pose diagnostic challenges. UV-induced fluorescence dermatoscopy (UVFD) is a novel dermatoscopy mode useful as a complementary diagnostic method in inflammatory dermatoses. The understanding of red fluorescence in psoriasis, caused by protoporphyrin IX, in regard to clinical-morphological features, site-dependency, geographic variability, and bleaching with sun-exposure remains very limited.

Diagnostic Accuracy of Polarized and Ultraviolet Fluorescence-Induced Dermoscopy in Scarring and Nonscarring Alopecias: a Retrospective Observational Multicentric Study.

Introduction: There is growing evidence that ultraviolet-induced fluorescence (UVF) dermoscopy may improve diagnostic accuracy in non-neoplastic dermatoses, yet data on hair disorders are scarce. The aim of this observational retrospective study was to compare the accuracy of polarized dermoscopy and UVF-dermoscopy in characterizing and distinguishing scarring and nonscarring alopecias.

Methods: A total of 84 patients were enrolled, with 43 and 41 patients suffering from nonscarring and scarring alopecias, respectively.

Dermoscopy of Scabies: Utility of Polarised and Ultraviolet-Induced Fluorescence Examination in Fair and Dark Skin.

Introduction: Ultraviolet-based dermoscopy may support the recognition of scabies, yet neither accuracy analyses nor data on skin of colour are available. The aim of this multicentric observational retrospective was to investigate the diagnostic accuracy of polarised and ultraviolet-induced fluorescence (UVF) dermoscopic examination in both fair and dark skin, also assessing possible differences according to the skin tone.

Methods: Consecutive patients with a diagnosis of scabies were eligible.

Pilot Study on High-Intensity Focused Ultrasound (HIFU) for Basal Cell Carcinoma: Effectiveness and Safety.

The rising incidence of Basal Cell Carcinoma (BCC), especially among individuals with significant sun exposure, underscores the need for effective and minimally invasive treatment alternatives. Traditional surgical approaches, while effective, often result in notable cosmetic and functional limitations, particularly for lesions located on the face. This study explores High-Intensity Focused Ultrasound (HIFU) as a promising, non-invasive treatment option that aims to overcome these challenges, potentially revolutionizing BCC treatment by offering a balance between efficacy and cosmetic outcomes.

Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.

Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma.

Dermoscopy of Lentiginous Melanomas and Equivocal Benign Pigmented Macules of the Scalp: A Case-Control Multicentric Study.

Introduction: Although the dermoscopic features of facial lentiginous melanomas (LM), including lentigo maligna and lentigo maligna melanoma, have been extensively studied, the literature about those located on the scalp is scarce. This study aims to describe the dermoscopic features of scalp LM and assess the diagnostic accuracy of dermoscopy to discriminate them from equivocal benign pigmented macules.

Methods: Consecutive cases of scalp LM and histopathology-proven benign but clinically equivocal pigmented macules (actinic keratoses, solar lentigos, seborrhoeic keratoses, and lichen planus-like keratoses) from four referral centres were included.