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This paper presents a magnetically isolated gate driver for the fast switching of IGBT (Insulated Gate Bipolar Transistor) in compact pulsed power sources with sharp rising edges and flat-top pulses for the application of electromagnetic launch and food processing. The proposed gate driver is implemented based on a planar transformer with a half-turn winding arrangement to increase the amplitude of the driving voltage pulse. With the half-turn winding arrangement, the leakage inductance of transformers decreases by 31.1% compared to the interleaving structure. This decrease enables a fast rise time of the driving voltage pulse. Furthermore, the gate drivers are used to drive the IGBT switching a Blumlein pulse forming network. The results show that the di/dt of the applied commercially available Si IGBT is about 10.10 A/ns with a gate voltage of 50 V and a gate capacitance charging time of about 88 ns, proving the effectiveness of the gate driver and providing a high-performance driving scheme for the fast switching of Si IGBT.
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http://dx.doi.org/10.1063/5.0214911 | DOI Listing |
Mar Environ Res
August 2025
Biodiversity Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Nangang, Taipei, 11529, Taiwan. Electronic address:
The global degradation of coral reefs threatens the persistence of fish assemblages, and protection-based management strategies alone may be insufficient to support their recovery. A key shortfall lies in the limited understanding of how habitat conditions shape fish recruitment along degraded reefs. In this study, we investigated how substrate composition, substrate rugosity, adult fish assemblages, and underwater soundscapes influence recruit abundance and richness.
View Article and Find Full Text PDFCancer Cell
July 2025
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:
Lung adenocarcinomas (LUAD) are a pressing global health problem with enduring lethality and rapidly shifting epidemiology. Proteogenomic studies integrating proteomics and post-translational modifications with genomics can identify clinical strata and oncogenic mechanisms, but have been underpowered to examine effects of ethnicity, smoking and environmental exposures, or sex on this heterogeneous disease. This comprehensive proteogenomic analysis of LUAD tumors and matched normal adjacent tissues from 406 patients across diverse geographic and demographic backgrounds explores the impact of understudied driver mutations, prognostic role of chromosomal instability, patterns of immune signaling, differential and sex-specific effects of endogenous mutagens and environmental carcinogens, and pathobiology of early-stage tumors with "late-like" characteristics.
View Article and Find Full Text PDFSci Rep
July 2025
School of Technology and Innovations, University of Vaasa, Vaasa, Finland.
This paper introduces a novel 13-level switched capacitor inverter. The proposed structure, comprising ten switches, five diodes, one input DC source, and five capacitors, can generate an alternating output voltage with a sixfold increase in the output load. The reduced number of switches lowers the cost of gate drivers, reducing the converter's volume and increasing its power density.
View Article and Find Full Text PDFPharmaceuticals (Basel)
June 2025
Department of Teacher Education, NLA University College, Linstows Gate 3, 0166 Oslo, Norway.
Dysregulated tyrosine kinase signaling is a central driver of tumorigenesis, metastasis, and therapeutic resistance. While tyrosine kinase inhibitors (TKIs) have revolutionized targeted cancer treatment, identifying compounds with optimal bioactivity remains a critical bottleneck. This study presents a robust machine learning framework-leveraging deep artificial neural networks (dANNs), convolutional neural networks (CNNs), and structural molecular fingerprints-to accurately predict TKI bioactivity, ultimately accelerating the preclinical phase of drug development.
View Article and Find Full Text PDFBiomaterials
February 2026
Research Center for Applied Sciences, Academia Sinica, Taipei, 115201, Taiwan. Electronic address:
Obesity-induced inflammation in visceral adipose tissue (VAT) is a major driver of metabolic dysfunctions, contributing to severe health conditions such as insulin resistance, diabetes, and fatty liver disease. Current anti-inflammatory therapies lack specificity, often leading to systemic immune suppression. To address this challenge, this study develops a nanosilicon-based hydrogen (H)-generating nanostructure coated with a positively charged copolymer layer, specifically designed for targeted immunomodulation within VAT.
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