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Objective: This study aimed to elicit expert consensus on the necessary components of a seclusion room module required to accommodate and manage psychiatric emergency patients requiring both medical and surgical interventions in infectious disease situations.
Methods: A two-round Delphi survey was conducted among 38 medical professionals, architects, and spatial design experts. The survey assessed the effectiveness, feasibility, and urgency of spatial scales, spatial organization, and movement system domains related to the necessary elements of a seclusion room.
Results: In the spatial scale domain, items such as "sufficient width to comply with disability standards (wheelchair accessible)" and "larger space should be provided for patients with a large range of motion or requiring special medical procedures" emerged as priorities. In the movement system domain, priorities included "anticipating situations where stable patients need to be pushed on a stretcher cart from both sides, necessitating a wider passage." In the spatial organization domain, priorities included "installing interior elements (wall images, media panels, etc.) that aid patient stability, although a separate area for patients' activities reflecting psychiatric characteristics is not necessary."
Conclusion: Expert consensus was achieved regarding the spatial scales, spatial organization, and movement system domains related to the necessary elements of a seclusion room for psychiatric emergency patients.
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http://dx.doi.org/10.30773/pi.2024.0193 | DOI Listing |
Nanoscale Horiz
September 2025
Programmable Biomaterials Laboratory, Institute of Materials, Interfaculty Bioengineering Institute, School of Engineering, Ecole Polytechnique Fédérale Lausanne, Lausanne, 1015, Switzerland.
The nanoscale spatial arrangement of T cell receptor (TCR) ligands critically influences their activation potential in CD8 T cells, yet a comprehensive understanding of the molecular landscape induced by engagement with native peptide-MHC class I (pMHC-I) remains incomplete. Using DNA origami nanomaterials, we precisely organize pMHC-I molecules into defined spatial configurations to systematically investigate the roles of valencies, inter-ligand spacings, geometric patterns, and molecular flexibility in regulating T cell function. We find that reducing the inter-ligand spacing to ∼7.
View Article and Find Full Text PDFJ Safety Res
September 2025
Center for Injury Research and Policy, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics, College of Medicine, The Ohio State University, Division of Epidemiology, College of Public Health, USA.
Background: Graduated Driver's Licensing (GDL) policies create an intermediate licensure phase for young novice drivers, and previous studies suggested that they reduce teen motor- vehicle crashes (MVCs). Multiple studies have shown that the effects of GDL laws vary in association with demographic factors and location, motivating estimation of sub-state policy effects. The present study estimates county-level effects of Ohio's 2007 enhanced GDL law on MVCs among 16-17-year-olds.
View Article and Find Full Text PDFNucleic Acids Res
September 2025
Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.
Spatial omics allow for the molecular characterization of cells in their spatial context. Notably, the two main technological streams, imaging-based and high-throughput sequencing-based, give rise to very different data modalities. The characteristics of the two data types are well known in spatial statistics as point patterns and lattice data.
View Article and Find Full Text PDFRedox Biol
September 2025
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA; Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA. Electronic address:
Mitochondria are central to cellular function, acting as metabolic hubs that regulate energy transduction to communicate cellular status. A key component of this energetic regulation is the mitochondrial membrane potential (MMP), a charge separation across the inner mitochondrial membrane generated by the electron transport chain. Beyond MMP's canonical role in driving ATP synthesis, MMP acts as a dynamic signaling hub.
View Article and Find Full Text PDFCien Saude Colet
August 2025
Programa de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina. Av. José Acácio Moreira 787, Humaitá. 88704-900 Tubarão SC Brasil.
The aim is to review the temporal trend and spatial distribution of reported cases of sexual violence in Brazil from 2013 to 2022. This is a mixed ecological study, descriptive of multiple groups, with a temporal trend analysis. Notifications of sexual violence from the Information System for Notifiable Diseases were reviewed.
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