Relationship Between CXCL11, CXCL13, CCL2, and CCL5 Gene Expression Levels and Allograft Function in Patients Undergoing Renal Transplant.

Objectives: Chemokines are inflammatory mediators directly involved in immunological mechanisms that mediate alloimmune responses; recently, gene expression analysis studies have aroused great interest in the field of transplantation. We aimed to evaluate the predictive role of chemokine gene expression in rejection in renal transplant patients.

Materials And Methods: Our study included 91 patients who underwent living-related renal transplant. Gene expression levels of chemokines were evaluated in urine samples collected preoperatively and postoperatively. Patients were followed up frequently in the clinic, and the relationship between chemokine levels and the development of acute rejection was investigated.

Results: The CXCL11 and CXCL13 gene expression levels at day 1 (P = .018 and P = .037), day 7 (P = .021 and P = .041), and month 1 (P = .039 and P = .039) after renal transplant were significantly higher in patients with acute rejection. CCL2 gene expression level was significantly higher in the group with acute rejection on day 1 (P = .038) and day 7 (P = .014) posttransplant. CCL5 expression level was higher in the group with acute rejection only on day 7 posttransplant (P = .027).

Conclusions: Follow-up of allograft function after renal transplant is of utmost importance. CXCL11, CXCL13, CCL2, and CCL5 gene expression levels may have roles in immune monitoring as they seem to have a potential to predict rejection.