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http://dx.doi.org/10.1016/j.htct.2024.06.011 | DOI Listing |
Invest Ophthalmol Vis Sci
September 2025
Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Purpose: Adeno-associated viruses (AAVs) have become the preferred vector for gene therapy in ophthalmology. However, requirements for specific cell surface receptors limit AAV-mediated retinal cell transduction efficiency. This led to the need to engineer novel AAV vectors for widespread retinal transduction and transgene expression.
View Article and Find Full Text PDFJ Chem Theory Comput
September 2025
International Center for Quantum and Molecular Structures, Faculty of Physics, Shanghai University, Shanghai 200444, China.
The representation of the electronic structure of benzene is important for understanding the properties of planar and monocyclic organic carbon compounds. Resonant Kekulé and conjugated structures based on localized and delocalized electronic theories, respectively, can be used to depict the ground state of benzene; however, depictions of its electrons vibrating in the excited states remain to be clarified. This paper presents a novel algorithm for exploring the three lowest lying vertically singlet excited states of benzene, focusing on the electronic excitations between occupied π and unoccupied π* orbitals.
View Article and Find Full Text PDFOMICS
September 2025
Centre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, India.
Wings apart-like protein (WAPL) has emerged as a key player in maintaining genome integrity through its regulation of cohesin dynamics, which govern chromatin architecture and gene expression. WAPL mainly acts as a cohesin release factor and ensures proper chromosomal segregation during mitosis by promoting sister chromatid resolution. Owing to its prominent role in cell biology, WAPL dysregulation can cause genomic instability and disrupt chromosomal cohesion, leading to diseases such as cancer.
View Article and Find Full Text PDFBr J Cancer
September 2025
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.
Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer.
Ann Anat
September 2025
Department of Biology, Faculty of Arts and Sciences, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.
The Anatolian ground squirrel (Spermophilus xanthoprymnus) offers a valuable model for investigating neuroadaptive processes in the retina during hibernation. This study aimed to assess the expression of vesicular glutamate transporter 1 (VGLUT1), glutamic acid decarboxylase (GAD) isoforms GAD65 and GAD67, and microtubule-associated protein 2 (MAP2) in the retina during pre-hibernation and hibernation states. Retinal tissues were analyzed using immunohistochemistry and densitometric quantification.
View Article and Find Full Text PDF