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Objectives: To provide population utility norms from the Health Utilities Index Mark 3 (HUI3) for the province of Quebec, Canada.
Methods: This study used data from the Care Trajectories Enriched Data (TorSaDE) cohort, which combines data from the Canadian Community Health Survey (CCHS) and the Quebec Provincial Insurance Board [Régie de l'assurance maladie du Quebec (RAMQ)]. The CCHS is a multiround health-related survey conducted by Statistics Canada since 2007. For each round spanning over 2 years, respondents were randomly selected and completed an online questionnaire. Quebec data for the HUI3 were available in the CCHS for rounds 2007, 2009, and 2013. The RAMQ database is an administrative database that contains information on health care services use and medical diagnostics. HUI3 scores were stratified by sociodemographic variables, as well as by self-reported health problems in the CCHS and by medical diagnostics from the RAMQ. Medical diagnostics were retrieved for the CCHS completion year and the year before and identifiable with the ICD-9 code in the RAMQ database.
Results: A total of 55,656 individuals were considered in this analysis. The mean (95% CI) and the median interquartile range of HUI3 were respectively 0.919 (0.918-0.919) and 0.973 (0.905-1) for the entire population. Individuals with lower scores were females, those aged 75 and over, divorced or widowed, unemployed during the last 12 months, less educated, or with a lower annual household income. Individuals born abroad and with normal weight of body mass index had higher utility scores. HUI3 score decreased with the number of diagnosed diseases from 0.946 (0.946-0946) for individuals without diagnosed disease to 0.682 (0.678-0.686) for individuals diagnosed with up to 18 diseases. Regardless of the number of diagnosed diseases in the RAMQ database, individuals who self-reported suffering from a single health problem presented a significantly lower HUI3 ranging from 0.944 (0.943-0.944) for Asthma to 0.789 (0.782-0.796) for Alzheimer compared with 0.956 (0.956-0.957) for individuals with no reported health problems. The same pattern was observed when considering individuals regardless of the diagnosed and self-reported diseases.
Conclusion: Utility score norms for HUI3 were produced in the general population of Quebec. Significant differences among various health problems were identified and norms can be used to compare populations in studies that do not have a control group.
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http://dx.doi.org/10.1097/MLR.0000000000002100 | DOI Listing |
Psychiatr Q
September 2025
Department of Psychological Counselling and Guidance, Yildiz Technical University, Istanbul, Türkiye.
Sleep is a significant factor influencing both physical and mental health. It supports thinking, emotional regulation, and vitality. However, insomnia is still a common problem, often linked to complex factors like psychological vulnerability and early life experiences.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Division of Infectious Diseases, Department of Medicine, University of Texas at Tyler School of Medicine, Tyler, Texas, USA.
Despite the long therapy duration, the treatment outcomes for lung disease (MAB-LD) are very poor. β-Lactams are among the recommended drugs for the treatment of MAB-LD; however, they are prone to hydrolysis by MAB β-lactamase enzymes. Therefore, β-lactamase inhibitors have been developed to overcome this problem.
View Article and Find Full Text PDFInt J Soc Psychiatry
September 2025
Department of Psychology at the Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK.
Background: Despite growing rates of common mental health disorders among country members of the Association of Southeast Asia Nations (ASEAN), there continue to be treatment gaps in these countries.
Aim: To systematically identify and synthesise barriers and facilitators to accessing formal psychological help for common mental health disorders in the existing literature.
Methods: APA PsycINFO, Web of Science, Scopus, and the Indonesian Portal Garuda were searched for studies reporting barriers or facilitators to individuals' engaging in formal psychological help-seeking for common mental health disorders in country members of ASEAN.
Phytochem Anal
September 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Introduction: The drug "alkaloids of Sophora flavescens" (ASF) is an extract from the dried root of S. flavescens Ai. It has various pharmacological effects including anti-arrhythmia, anti-inflammatory, anti-allergic, anti-hepatitis, and antimicrobial.
View Article and Find Full Text PDFCochrane Database Syst Rev
September 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Background: Radiotherapy is the mainstay of treatment for head and neck cancer (HNC) but may induce various side effects on surrounding normal tissues. To reach an optimal balance between tumour control and toxicity prevention, normal tissue complication probability (NTCP) models have been reported to predict the risk of radiation-induced side effects in patients with HNC. However, the quality of study design, conduct, and analysis (i.
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