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Article Abstract
Introduction: Bone and joint infections (BJIs) caused by multidrug-resistant bacteria are becoming more frequent. However, data on the use of novel β-lactam/β-lactamase inhibitors, such as imipenem/cilastatin/relebactam (I-R) and meropenem/vaborbactam (MVB), to treat BJIs is lacking. Furthermore, prolonged infusions of these β-lactams should theoretically optimize pharmacokinetic/pharmacodynamics target in these indications, but there are currently no reports on this type of infusions, especially in the setting of BJI.
Case Presentation: We report a case of a vertebral osteomyelitis caused by carbapenem-resistant successfully treated with extended-infusion of I-R (1.25 g q6h over 2 h), then with continuous infusion of MVB (2 g q4h as over 4 h). Therapeutic drug monitoring confirmed that extended-infusion of I-R and continuous infusion of MVB achieved serum concentrations up to 12 mg/L of imipenem and 19 mg/L of meropenem, respectively.
Conclusion: The favourable outcome of this patient treated for a vertebral osteomyelitis caused by carbapenem-resistant suggest that extended- and continuous infusions of I-R and MVB, are promising regimens for treatment of BJIs caused by carbapenem-resistant Enterobacterales.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561750 | PMC |
| http://dx.doi.org/10.3389/fphar.2024.1347306 | DOI Listing |
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