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http://dx.doi.org/10.1186/s40001-024-02145-3 | DOI Listing |
Scand J Surg
September 2025
Department of Gastrointestinal surgery, Stavanger University Hospital, Stavanger, Norway.
Background And Aims: Acute appendicitis is the most common surgical emergency worldwide. Obtaining a correct diagnosis and timely management can be challenging even in modern medicine. Hence, appendicitis is still considered a "high-risk" diagnosis for litigation and claims of malpractice.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
September 2025
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Purpose: The Food and Drug Administration Adverse Event Reporting System (FAERS) is an important source of information on suspected adverse drug reactions, but does not standardise drugs. The Adverse Event Open Learning Through Universal Standardization (AEOLUS) System Provides Standardisation of drugs in FAERS to RxNorm, but its coverage leaves room for improvement and mapping accuracy has not been established. Furthermore, drugs are not mapped to the Anatomical Therapeutic Chemical (ATC) Classification System, which is frequently used in pharmacovigilance studies.
View Article and Find Full Text PDFClin Exp Nephrol
September 2025
Nephrology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Background: ED is commonly encountered among male CKD patients. SGLT2Is were recently recommended as a universal treatment for CKD. It's hypothesized that the mechanism of action of SGLT2Is could be related to improving endothelial dysfunction.
View Article and Find Full Text PDFFamilial dysautonomia (FD) is a rare autosomal recessive neurodegenerative disorder caused by a splicing mutation in the gene. It predominantly affects the sensory and autonomic nervous systems, with progressive vision loss due to optic neuropathy being a universal and debilitating symptom. Retinal pathology in FD involves progressive thinning of the retinal nerve fiber layer (RNFL), resulting from the degeneration of retinal ganglion cells (RGCs).
View Article and Find Full Text PDFCurr Issues Mol Biol
August 2025
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
Enhancing the specificity and applicability of PCR-based genome-walking methods is highly desirable. A new and universal genome-walking tool, called center degenerated walking-primer PCR (CDWP-PCR), is presented in this study. CDWP-PCR involves adopting a center degenerated walking primer (cdWP) in the secondary/tertiary round of amplification.
View Article and Find Full Text PDF