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Sophisticated high-fidelity simulations can predict bone mass density (BMD) changes around a hip implant after implantation. However, these models currently have high computational demands, rendering them impractical for clinical settings. Model order reduction techniques offer a remedy by enabling fast evaluations. In this work, a non-intrusive reduced-order model, combining proper orthogonal decomposition with radial basis function interpolation (POD-RBF), is established to predict BMD distributions for varying implant positions. A parameterised finite element mesh is morphed using Laplace's equation, which eliminates tedious remeshing and projection of the BMD results on a common mesh in the offline stage. In the online stage, the surrogate model can predict BMD distributions for new implant positions and the results are visualised on the parameterised reference mesh. The computational time for evaluating the final BMD distribution around a new implant position is reduced from minutes to milliseconds by the surrogate model compared to the high-fidelity model. The snapshot data, the surrogate model parameters and the accuracy of the surrogate model are analysed. The presented non-intrusive surrogate model paves the way for on-the-fly evaluations in clinical practice, offering a promising tool for planning and monitoring of total hip replacements.
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http://dx.doi.org/10.1007/s10237-024-01903-w | DOI Listing |
Eur Heart J Cardiovasc Pharmacother
September 2025
Department of Internal Medicine, University of Genova, Genova, Italy.
Aims: Several diuretic strategies, including furosemide iv boluses (FB) or continuous infusion (FC), are used in acute heart failure (AHF).
Methods And Results: We systematically searched phase 3 randomized clinical trials (RCTs) evaluating diuretic regimens in admitted AHF patients within 48 hours and irrespective of clinical stabilization. We calculated the odds ratio (OR) of FC or FB plus another diuretic (sequential nephron blockade, SNB) compared to FB alone on 24-hour weight loss (WL) and worsening renal function (WRF), with a random-effects model with inverse variance weighting.
J Phys Chem A
September 2025
Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14850, United States.
Ionic liquids (ILs) have been gaining increasing focus in a variety of applications including emerging electric-propulsion concepts. A quantitative understanding of how IL ions fragment during high-energy collisions with background gases is therefore essential for interpreting mass spectra, predicting ion lifetimes in plasma and vacuum environments, and designing IL-based technologies. This work uses molecular dynamics (MD) simulations with a reactive force field to numerically model the collision-induced dissociation (CID) of isolated ions (both positive and negative) and ion clusters (2:1 and 1:2 clusters) of the prototypical ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM-BF), colliding with a nitrogen (N) molecule, exploring all possible fragmentation channels arising from the breaking of both ionic and covalent bonds at collision energies ranging from 10 electron volts (eV) to 100 electron volts (eV) in the laboratory frame.
View Article and Find Full Text PDFMed Phys
September 2025
Department of Radiology, Keio University School of Medicine, Tokyo, Japan.
Background: Understanding respiratory motions of liver and its surrogate organs is crucial for precise dose delivery in liver cancer radiotherapy. Although these motions have been studied for respiratory motion management in the supine posture, few studies have quantified them and evaluated their correlations in the upright posture.
Purpose: This study quantified the respiratory motions of liver and surrogate organs and evaluated the correlations between the liver motions and surrogate signals for respiratory motion monitoring in both the supine and upright postures.
J Mech Behav Biomed Mater
September 2025
Center for Applied Biomechanics, University of Virginia, 4040 Lewis and Clark Drive, Charlottesville, VA, 22911, United States.
Seatbelt-induced pelvic iliac wing injuries have been observed since the 1970s, but only recently has there been quantification of fracture tolerance and injury risk of the iliac wing. Previous studies have shown a wide variation in iliac wing fracture tolerance with no significant relationships to pelvis size, sex, or other factors. A weighted average bone density (BD) calculation of the entire iliac wing produced the best predictive performance of fracture tolerance in parametric (Weibull) survival models.
View Article and Find Full Text PDFComput Methods Biomech Biomed Engin
September 2025
College of Information Science and Technology, Donghua University, Shanghai, China.
High cost of clinical trials hinders further enhancement of comprehensive mechanical properties of bioresorbable scaffolds (BRS). Therefore, a multi-objective optimization method combining surrogate modeling and finite element simulation is proposed, based on the evaluation of stents with various auxetic structures and materials. The results demonstrated that re-entrant hexagon stent made of PLA (PLA-RH stent) was a more ideal candidate, with superior radial recoil and force.
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