Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Hypothyroidism (HT) affects millions worldwide and can lead to various lipid disorders. The metabolic complexity and the influence of toxic elements in autoimmune and non-autoimmune HT subtypes are not fully understood. This study aimed to investigate the relationships between plasma lipidome, toxic elements, and clinical classifications of HT in unexposed individuals.
Methods: Samples were collected from 120 adults assigned to a study group with Hashimoto's disease and non-autoimmune HT, and a healthy control group. Quantification of 145 pre-defined lipids was performed by using triple quadrupole tandem mass spectrometry (TQ MS/MS) in multiple reactions monitoring (MRM) mode via positive electrospray ionization (ESI). Levels of toxic elements were determined using inductively coupled plasma mass spectrometry (ICP-MS).
Results: Significant associations between altered levels of several components of the plasma lipidome and Al, Cd, Ni, As, and Pb with HT were found. We show metabolic differences in lysophosphatidylcholines (LPC) and phosphatidylcholines (PC) between HT and controls, with distinct predicted activation patterns for lysolecithin acyltransferase and phospholipase A2.
Conclusions: There are significant changes in the lipidome profiles of healthy subjects compared to euthyroid HT patients treated with L-thyroxine, which are related to the type of hypothyroidism and non-occupational exposure to toxic elements.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547455 | PMC |
| http://dx.doi.org/10.3390/molecules29215169 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic antibacterial action of AgNP-ampicillin conjugates: Evading β-lactamase degradation in ampicillin-resistant clinical isolates.
PLoS One
September 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Objectives: Antibiotic resistance towards penicillin has been attempted to counter by chemically modifying ampicillin through the conjugation with silver nanoparticles (AgNPs). The current study optimizes the conditions for synthesizing and characterizing AgNP-ampicillin to quantify the conjugation extent, evaluate the antibacterial efficacy, and explore the underlying antibacterial mechanisms.
Materials And Methods: AgNPs were synthesized from silver nitrate by chemical reduction method, silica-coated with tetraethyl orthosilicate (TEOS) and amine functionalized by (3-aminopropyl) triethoxysilane (APTES), which was then conjugated with ampicillin via the carbodiimide chemistry.
Understanding financial hardship in families of people living with dementia: Protocol for a scoping review to identify subjective self-report measures that evaluate financial hardship.
PLoS One
September 2025
School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Background: Financial hardship (including financial stress, financial strain, asset depletion, and financial toxicity) is a highly relevant construct among the 6.9 million people living with Alzheimer's disease and related dementias (ADRD) in the United States and their family networks. This scoping review will identify existing measures and approaches for capturing financial strain among these families.
View Article and Find Full Text PDFHealth benefits of selenium through the consumption of fresh wild macromycetes from Dali, Yunnan, China.
Food Res Int
November 2025
Medical University of Lodz, Faculty of Pharmacy, Department of Toxicology, 1 Muszyńskiego Street, 90-151 Łódź, Poland. Electronic address:
The beneficial effects of dietary selenium in countering mercury toxicity are increasingly being explored. This information would be particularly useful in Se-deficient regions, such as parts of the Yunnan, where wild fungi are a popular and sustainable food source. Selenium and mercury were analysed in multiple specimens of unprocessed and stir-fried fruiting bodies of bolete fungi.
View Article and Find Full Text PDFComprehensive study on selenium- and zinc-enriched duck embryo egg powder: component analysis, safety evaluation and prostate protection effect.
J Sci Food Agric
September 2025
Key Laboratory of Egg Processing, Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, China.
Background: Selenium and zinc elements have been proven to participate in immune regulation and infertility improvement. Their potential has been confirmed in in prostatitis and reproductive performance modulation. In this study, first the composition of selenium- and zinc-enriched duck embryo egg (SZDE) powder was analyzed, especially trace elements and oligopeptides.
View Article and Find Full Text PDFInsights into the Evolutionary and Ecological Roles of in Arsenic Detoxification.
Environ Sci Technol
September 2025
Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, Hangzhou 310058, China.
Arsenic (As) is a prevalent toxic element, posing significant risks to organisms, including microbes. While microbial arsenic detoxification has been extensively studied in bacteria, archaeal mechanisms remain understudied. Here, we investigated arsenic resistance genes in , one of the most abundant archaeal lineages on Earth.
View Article and Find Full Text PDF