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http://dx.doi.org/10.1002/mdc3.14250 | DOI Listing |
Sensors (Basel)
August 2025
School of Electrical and Data Engineering, University of Technology Sydney, 15 Broadway, Ultimo, Sydney, NSW 2007, Australia.
Extrapyramidal symptoms encompass features of Parkinsonism, including bradykinesia, cogwheel rigidity, and resting tremors, which contribute to motor impairments hindering handwriting and speech. In this study, we analyzed voice data captured using a voice sensor setup from 94 patients exhibiting varying levels of EPS and 30 unaffected controls. Each participant provided 13 recordings of repeated vowel and consonant sounds.
View Article and Find Full Text PDFToxins (Basel)
August 2025
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Tremor, an oscillatory movement disorder, is commonly encountered in clinical practice in the setting of a variety of etiologies, such as essential tremor and Parkinson's disease. Despite its high prevalence, treatment options are somewhat limited. Oral medications are often ineffective or limited by side effects, and other treatments, such as deep brain stimulation, are more invasive and costly.
View Article and Find Full Text PDFObjective: Tremor is a common presenting concern and is associated with a wide range of potential etiologies. This article reviews the approach to the clinical evaluation of tremor, the diagnosis of essential tremor, differential diagnoses, and management options.
Latest Developments: Although new investigational drugs are being studied, no medication besides propranolol has been approved by the US Food and Drug Administration (FDA) as a treatment for essential tremor.
NPJ Parkinsons Dis
July 2025
Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
While bilateral high-frequency subthalamic nucleus stimulation (Bi-HFS) frequently worsens speech in Parkinson's disease (PD), low-frequency stimulation (LFS) may alleviate gait deficits but lacks robust evidence for speech benefits. This randomized trial compared Bi-LFS (60 Hz) and Bi-HFS (130 Hz) in 33 PD patients with postural instability/gait difficulty (PIGD), and evaluated asymmetric frequency stimulation (AFS) in 20 patients. Bi-LFS significantly improved dysphonia severity index (DSI, FDR-p = 0.
View Article and Find Full Text PDFCureus
May 2025
General Surgery, Hospital Español, Mexico City, MEX.
Vagus nerve paragangliomas (PGL) are tumors derived from neural crest cells of very low incidence, and cervical PGL of the vagus nerves (VPGLs) are tumors, of which the nature and location make them extremely rare, representing only 0.012% of cervical tumors, with an incidence of 1:30,000-1:200,000. A 76-year-old woman presented with a rapid growth in volume in the left laterocervical region, accompanied by pain for four months.
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