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The medical metaverse can be defined as a virtual spatiotemporal framework wherein higher-dimensional medical information is generated, exchanged, and utilized through communication among medical personnel or patients. This occurs through the integration of cutting-edge technologies such as augmented reality (AR), virtual reality (VR), artificial intelligence (AI), big data, cloud computing, and others. We can envision a future neurosurgical operating room that utilizes such medical metaverse concept such as shared extended reality (AR/VR) of surgical field, AI-powered intraoperative neurophysiological monitoring, and real-time intraoperative tissue diagnosis. The future neurosurgical operation room will evolve into a true medical metaverse where participants of surgery can communicate in overlapping virtual layers of surgery, monitoring, and diagnosis.
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http://dx.doi.org/10.3340/jkns.2024.0160 | DOI Listing |
PLoS Negl Trop Dis
September 2025
Department of Medical Microbiology and Infectious Diseases Rotterdam, Erasmus Medical Center, University Medical Centre, Rotterdam, The Netherlands.
Eumycetoma is a neglected tropical subcutaneous disease most commonly caused by the fungus Madurella mycetomatis. Currently, eumycetoma is treated by a combination of antifungal therapy and surgery, with limited success rates. To identify novel drug targets we used an in silico approach to determine the kinases present in M.
View Article and Find Full Text PDFObjectives: In physical reality, mobility limitations often hinder the ability of older individuals to fully interact with the world. Aging increases the likelihood of a decline in social activities. New technologies, including immersion technologies, are increasingly gaining attention as society grapples with the challenges of an aging population.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8 T-cells directed against HLA-B*15:01-restricted Spike-derived S peptide (B15/SCD8 T-cells). However, fundamental questions remained on the abundance and clonotypic nature of CD8 T-cell responses in HLA-B*15:01-positive patients who succumbed to life-threatening COVID-19.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Gastroenterology, Fuxin Central Hospital, Liaoning, China.
With the rapid development of immersive technologies such as virtual reality (VR) and augmented reality (AR), the Metaverse is emerging as a transformative platform in medical education. This study examines the integration of the Metaverse into surgical clinical teaching, highlighting its potential to enhance educational outcomes, overcome traditional limitations, and foster global collaboration in medical training. Core features of the Metaverse offer medical students a safe virtual setting for practicing complex surgical procedures and honing clinical decision-making skills.
View Article and Find Full Text PDFSci Rep
August 2025
Department of Ophthalmology, Graduate School of Medicine, The University of Osaka, Suita, Japan.
This study aimed to compare the number of peripapillary perforating scleral vessels (PPSVs) between eyes with and without glaucoma. A retrospective case-control analysis was performed on patients with glaucoma and control participants who underwent swept-source optical coherence tomography (SS-OCT) at a single institution. The number of PPSVs around the optic disc was counted on deep-learning assisted en face SS-OCT images created from 6 × 6 mm peripapillary volumetric scans.
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