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Background: Unlike acute appendicitis, chronic appendicitis is characterized by nonspecific abdominal pain and intermittent course. This may lead to late diagnosis or misdiagnosis, with the possibility of serious complications.
Case Report: A male patient of Arab origin aged 55 years had a 2-year history of recurrent episodes of mild pain in the right lower quadrant of the abdomen. The episodes were associated with nausea, chills, and abdominal bloating but no vomiting, rectal bleeding, or weight loss. On examination, the patient showed soft and lax abdomen with mild tenderness in the right lower quadrant, with no organomegaly or abdominal masses. Laboratory findings showed normal complete blood count and C-reactive protein. The patient underwent colonoscopy to rule out malignancy, which showed appendiceal orifice polyp that required resection. The computed tomography scan showed an enlarged appendix with multiple intraluminal dense appendicoliths. The largest stone at the appendiceal orifice measured 1.5 cm × 0.9 cm and was partially protruding within the cecal lumen. The diagnosis of chronic appendicitis was confirmed. The patient underwent appendectomy and was asymptomatic a few days after discharge.
Conclusions: We are reporting a patient with chronic appendicitis presented with multiple appendicoliths. The patient was initially misdiagnosed as periappendiceal orifice polyp. The current finding highlights the importance of imaging, especially computed tomography in confirming the diagnosis in patients with atypical appendicitis presentation.
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http://dx.doi.org/10.1186/s13256-024-04847-y | DOI Listing |
PLoS Med
September 2025
Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Although the fecal immunochemical test (FIT) is widely utilized in colorectal cancer (CRC) screening because of its noninvasive, rapid, and cost-effective characteristics, its effectiveness in post-adenoma resection surveillance remains unclear. This study aims to evaluate the benefits of follow-up FIT surveillance in individuals with adenoma resection and to identify risk factors associated with adenoma recurrence.
Methods And Findings: As part of China's National Screening Project, we identified a total of 5,911 individuals who underwent adenoma removal during the first round of CRC screening in Jiashan and Haining between 2006 and 2021.
Background: The efficacy and safety of secukinumab up to week 52 in children and adolescents with moderate-to-severe chronic plaque psoriasis have been demonstrated previously (NCT03668613). Herein, we report the long-term efficacy, safety, and tolerability of secukinumab over a period of up to 208 weeks.
Methods: In this randomized open-label trial, patients (6 to < 18 years) were randomized 1:1 to receive low-dose (LD; N = 42) or high-dose (HD; N = 42) secukinumab stratified by weight (< 25 kg, 25 to < 50 kg, or ≥ 50 kg) and disease severity (moderate or severe).
Ann Epidemiol
August 2025
School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia. Electronic address:
Background: Colorectal cancer represents a major concern in China, coupled with a low rate of diagnostic colonoscopy, emphasising the necessity for improved adherence to diagnostic colonoscopy.
Objective: We aimed to predict colonoscopy behaviour in middle-aged and elderly adults using machine learning, explore determinants, and develop a web-based tool to improve adherence to diagnostic colonoscopy.
Methods: We used 49,418 consultation data with positive results of colorectal cancer preliminary screening (defining a positive result in risk assessment or FOBT screening as a preliminary screening positive) from a total of 202,091 consultations in a community-based colorectal cancer screening program between 2013 and 2021 from Baoshan District, Shanghai, China.
Int J Surg Case Rep
September 2025
Adera Medical and Surgical Center, Addis Ababa 1000, Ethiopia.
Introduction And Importance: Crohn's disease (CD) is a chronic, transmural inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract. Its rare involvement of the appendix can mimic acute appendicitis, often leading to misdiagnosis and inappropriate initial management.
Case Presentation: We report three patients who presented with right lower quadrant abdominal pain and were initially diagnosed and surgically treated for acute appendicitis.
Int J Emerg Med
August 2025
Department of Emergency Medicine and Critical care, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Introduction: Acute abdomen during early pregnancy poses a diagnostic challenge, especially in patients with underlying chronic gastrointestinal diseases.
Case Report: A 36-year-old woman with Crohn’s disease and a confirmed 6-week intrauterine pregnancy presented with diffuse abdominal pain. Initial investigations, including MRI and ultrasound, were inconclusive.