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Background And Objectives: Malignant melanoma affects younger working individuals. This study investigated work ability and sick leave within one year after diagnosis, as well as the impact of rehabilitation and psycho-oncological measures on employment outcomes.
Patients And Methods: In this monocentric, prospective, observational cohort study, 221 patients (62.4% females), aged 19-65, participated. 78.5% had tumor stage IB or lower at baseline. Routine clinical documentation, occupational history, work ability, subjective prognosis of employment, need for and satisfaction with rehabilitation measures were repeatedly assessed.
Results: 181 patients (82%) were employed at first visit, 172 (78%) at last visit. Approximately 75% of patients initially rated work ability as "moderate", with up to 9 sick leave days. In the following year, sick days increased significantly in patients with stage IB and IIA (p = 0.044) and highly significantly in patients with stage II B and above (p < 0.001). Psycho-oncologic consultation (24%) and rehabilitation (18%) did not change the significantly worse self-rated work ability of these patients.
Conclusions: Melanoma affects work ability, even in tumor stages without lymph node involvement or distant metastasis. Controlled clinical trials would be useful to evaluate the success of rehabilitation and psycho-oncological interventions for patients with melanoma.
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http://dx.doi.org/10.1111/ddg.15560 | DOI Listing |
Cereb Cortex
August 2025
Faculty of Psychology and Education Science, Department of Psychology, University of Geneva, Chemin des Mines 9, Geneva, 1202, Switzerland.
Language learning and use relies on domain-specific, domain-general cognitive and sensory-motor functions. Using fMRI during story listening and behavioral tests, we investigated brain-behavior associations between linguistic and non-linguistic measures in individuals with varied multilingual experience and reading skills, including typical reading participants (TRs) and dyslexic readers (DRs). Partial Least Square Correlation revealed a main component linking cognitive, linguistic, and phonological measures to amodal/associative brain areas.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Bioengineering, Stanford University, Stanford, CA 94305.
Despite periods of permanent darkness and extensive ice coverage in polar environments, photosynthetic ice diatoms display a remarkable capability of living inside the ice matrix. How these organisms navigate such hostile conditions with limited light and extreme cold remains unknown. Using a custom subzero temperature microscope during an Arctic expedition, we present the finding of motility at record-low temperatures in a Eukaryotic cell.
View Article and Find Full Text PDFTissue Eng Regen Med
September 2025
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #505 BanPo-Dong, SeoCho-Gu, Seoul, 06591, Republic of Korea.
Background: Sjögren's syndrome (SS) is a chronic autoimmune disease delineated by excessive lymphocyte infiltration to the lacrimal or salivary glands, leading to dry eye and dry mouth. Exosomes secreted from mesenchymal stem cells (MSC) are known to have anti-inflammatory and tissue regeneration abilities. This study endeavored to demonstrate the effect of MSC-derived exosomes on the clinical parameter of dry eyes and associated pathology in SS mouse model.
View Article and Find Full Text PDFAppl Environ Microbiol
September 2025
DGIMI, Université de Montpellier, INRAE, Montpellier, France.
is an entomopathogenic bacterium involved in a mutualistic relationship with nematodes. produces a multitude of specialized metabolites by non-ribosomal peptide synthetase (NRPS) pathways to mediate bacterium-nematode-insect interactions. PAX cyclolipopeptides are a family of NRP-type molecules whose ecological role remains poorly understood.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Department of Chemistry, McGill University, Montreal, Quebec H3A 0G4, Canada.
Semiconductor quantum dots (QDs) are well known to give rise to a quantum confined structure of excitons. Because of this quantum confinement, new physics of hot exciton relaxation dynamics arises. Decades of work using transient absorption (TA) spectroscopy have yielded initial simple observations, such as estimates of the cooling rate from single pump photon energy experiments.
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