Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1513/AnnalsATS.202404-414RL | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spirometry thresholds for clinical trial eligibility: time for urgent re-evaluation.
Thorax
September 2025
Clinical Trials Accelerator Platform, London, UK
A common eligibility criterion in respiratory clinical trials is a per cent-predicted forced expiratory volume in 1 second (ppFEV) between 40% and 90%, using the ethnicity-dependent Global Lung Function Initiative (GLI)-2012 spirometry reference equations. International societies now endorse the newer 'race-neutral' GLI-Global equations. We quantify the impact on trial eligibility of switching from GLI-2012 to GLI-Global for the UK Cystic Fibrosis Registry (n=8182).
View Article and Find Full Text PDFImpact of race-based spirometry equations on guideline-based asthma management in clinical trials.
J Allergy Clin Immunol
August 2025
The University of Wisconsin School of Medicine and Public Health, Madison.
Background: The American Thoracic Society recently recommended that race- and ethnicity-specific predicted equations for spirometry be replaced with race-neutral equations. This change could have implications for asthma management.
Objective: Our aim was to examine the effect of race-specific versus race-neutral spirometry reference equations on the resultant guideline-directed asthma therapy in a study population with a high proportion of Black children.
Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development.
EMBO J
August 2025
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Formation of skin epithelial appendages like hair follicles requires hedgehog (Hh) signal reception, its conduction through the primary cilium and activation of Gli transcription factors. How Hh signalling induces cell-type-specific responses through Gli transcription factors in hair follicle stem cells and their cilia-dependence remains unclear. Here, we use conditional mouse mutants to genetically dissect the roles of Gli2 and Gli3 transcription factors and cilia in the skin epithelium.
View Article and Find Full Text PDFBody Mass Index Impacts on Gray Matter Volume in Developmental Restrictive Anorexia Nervosa: A Voxel-Based Morphometry Study.
Nutrients
August 2025
IRCCS Stella Maris Foundation, Viale del Tirreno 331, 56128 Pisa, Italy.
Previous magnetic resonance imaging (MRI) investigations reported brain alterations in anorexia nervosa restricting type (AN-R); however, the number of existing structural neuroimaging studies in the developmental age is limited. Here, we analyzed the volumetric brain differences between adolescent patients with AN-R and control peers, and possible correlations between brain volumes and clinical features. The sample comprised 47 adolescent females with AN-R (mean age: 15.
View Article and Find Full Text PDFComparative studies of the NO impacts on the photooxidation mechanisms of isomeric monoterpenes of β-pinene and limonene.
J Environ Sci (China)
December 2025
State Key Laboratory of Molecular Reaction Dynamics and Dalian Coherent Light Source, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute of Advanced Science Facilities, Shenzhen 518107,
It is highly challenging to precisely compare the impacts of anthropogenic pollutants on the photooxidation of isomeric volatile organic compounds with respect to molecular compositions and particle number/mass concentrations of secondary organic aerosols (SOAs). In this study, we conducted a series of well-defined indoor chamber experiments to compare the effects of NO (NO and NO) on the photooxidation of isomeric monoterpenes of β-pinene and limonene. For the photooxidation of β-pinene with NO, the increase of the initial concentrations of NO ([NO]) shows a monotonous suppression of the particle mass concentration, whereas the increase of [NO] shows a monotonous enhancement of the particle mass concentration.
View Article and Find Full Text PDF