Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We studied interrelationships between behavioral parameters, metabolic processes, and cytokine content in the blood of male and female rats at different stages of postnatal ontogeny after intrauterine stress (mothers were forced to swim in cold water from the 10th to the 16th day of pregnancy). Correlations between behavioral and metabolic parameters in prenatally stressed rats were revealed at an earlier age (day 21 of life) than in controls. In comparison with intact rats, in males exposed to intrauterine stress no relationships between these parameters were revealed at older age, while in females, their direction and character change on day 60 of life. In prenatally stressed males, correlations of the blood levels of IL-6 were revealed: inverse relationships with behavioral parameters on the days 21 and 30 and direct relationships with metabolic parameters on day 60 of life. In prenatally stressed females on day 30 of life, we observed negative correlations between IL-4 levels and metabolic parameters that were absent under normal conditions. Thus, intrauterine stress leads to reorganization of the relationships between the parameters of metabolic and immune processes, which are essential for the purposeful behavior of mammals. The effects of stress seem to depend on the sex of the offspring and stage of postnatal development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-024-06252-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of the ONSTEP and Lichtenstein techniques for inguinal hernia repair-early results of a prospective study.
Pol Merkur Lekarski
September 2025
DEPARTMENT OF GENERAL, ONCOLOGIC AND METABOLIC SURGERY, INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE, WARSAW, POLAND.
Objective: Aim: The study aims to evaluate the impact of the ONSTEP technique on the intensity of the systemic inflammatory response syndrome (SIRS) and the outcomes of inguinal hernia treatment compared to the Lichtenstein technique. .
Patients And Methods: Materials and Methods: In 41 men randomized into 2 study groups, unilateral inguinal hernia repair was performed using the ONSTEP technique in group O and the Lichtenstein technique in group L.
Insights into impact of polar protic and aprotic solvents on bioactive features of 3-(Dimethylaminomethyl)-5-nitroindole: A DFT study and molecular dynamics simulations.
PLoS One
September 2025
Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Polar protic and aprotic solvents can effectively simulate the maturation of breast carcinoma cells. Herein, the influence of polar protic solvents (water and ethanol) and aprotic solvents (acetone and DMSO) on the properties of 3-(dimethylaminomethyl)-5-nitroindole (DAMNI) was investigated using density functional theory (DFT) computations. Thermodynamic parameters retrieved from the vibrational analysis indicated that the DAMNI's entropy, heat capacity, and enthalpy increased with rising temperature.
View Article and Find Full Text PDFThe contribution of the brain-gut-microbiome axis to intergenerational abnormalities in a rat model of perioperative neurocognitive disorder.
Anesthesiology
September 2025
Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida.
Background: The brain-gut-microbiome (BGM) axis is a communication network through which the brain and gastrointestinal microbiota interact via neural, hormonal, immune, and gene expression mechanisms. Gut microbiota dysbiosis is thought to contribute to neurocognitive disorders, including perioperative neurocognitive disorder (PND), and to various metabolic abnormalities. Recently, we reported that sevoflurane induces neurocognitive deficits in exposed rats as well as their future offspring, with male offspring being particularly affected (intergenerational PND).
View Article and Find Full Text PDFTherapeutic Effect of Physical Activity in a Male Wistar Rat Model of Paraquat and Maneb-Induced Parkinson's Disease.
Neurochem Res
September 2025
Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Parkinson's disease (PD) is characterized by impairments in motor control following the degeneration of dopamine-producing neurons located in the substantia nigra pars compacta. Environmental pesticides such as Paraquat (PQ) and Maneb (MB) contribute to the onset of PD by inducing oxidative stress (OS). This study evaluated the therapeutic efficacy of moderate physical activity (PA) on both motor and non-motor symptoms in a Wistar rat model of Paraquat and Maneb (PQ/MB) induced PD.
View Article and Find Full Text PDFMonitoring of shallow groundwater in Lower Saxony, Germany-spatial variability of redox conditions and benefit of the redox proxy ∆.
Environ Monit Assess
September 2025
Department of Geosciences, University of Bremen, Bremen, Germany.
Surveillance monitoring of shallow groundwater revealed that redox conditions can vary on a small scale. Therefore, the aim of this study was to categorize redox conditions in the groundwater of Lower Saxony, Germany, and to analyze the spatial distribution and trends of parameters related to redox conditions during surveillance monitoring from 1957 to 2015 in Lower Saxony, Germany. Methodically, trends were considered by applying the Mann-Kendall test and redox conditions of groundwater were classified according to the scheme of Jurgens et al.
View Article and Find Full Text PDF