[The role of neuroinflammation in the development of seizure activity and autonomic disorders in patients with epilepsy].

The literature review provides data on the role of neuroinflammation, including microglial and astrocyte dysfunction, in the development of increased neuronal excitability and excitotoxicity, which can lead to increased seizure activity. The ability of reactive astrocytes to uptake glutamate through specific transporters is reduced, leading to increased cell excitability, excitotoxicity, and, consequently, the occurrence of epileptogenic activity. In general, neuroinflammation is associated with the activation of neuroplasticity, which can be of a maladaptive (aberrant) nature.

Behavioral Characteristics of Female Rats on the Model of Pain Syndrome in the Maxillofacial Region.

Changes in behavioral parameters in the open field and elevated plus maze tests were studied in female rats with experimental osteoarthritis of the temporomandibular joint (TMJ) caused by intra-articular injection of sodium monoiodoacetate (16 mg/kg). In the elevated plus maze, the animals with experimental pain syndrome demonstrated the following dynamics of behavioral parameters: the latency of leaving the central platform and the time spent in closed arms increased, while the number of visits to closed arms and numbers of head dips and rearings decreased on day 25 of the experiment in comparison with the baseline levels. In the open-field, the latency of the first movement and grooming time increased and the number of objects explored decreased by day 26.

The Effect of Rhythmic Optical Stimulation on Temporal Parameters of Human Sensorimotor Response and Their Relation to the Spectral Characteristics of the Initial EEG.

The effect of optical stimulation at a frequency of 10 Hz (OS) on temporal parameters of sensorimotor activity in healthy subjects (n=32) was studied. The expression of the activation response was determined by the ratio of spectral power values (SPα2, μV) of the high frequency (10-13 Hz) subrange of the α-rhythm of the initial EEG with closed and opened eyes and the frequency of the maximum α-peak (IAPF). A test for simple motor reaction time was performed under normal and OS conditions.