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http://dx.doi.org/10.1016/j.jacadv.2024.101299 | DOI Listing |
Biol Pharm Bull
September 2025
Computational and Biological Learning Laboratory, University of Cambridge, Cambridge CB21PZ, United Kingdom.
Neuroimaging in rodents holds promise for advancing our understanding of the central nervous system (CNS) mechanisms that underlie chronic pain. Employing two established, but pathophysiologically distinct rodent models of chronic pain, the aim of the present study was to characterize chronic pain-related functional changes with resting-state functional magnetic resonance imaging (fMRI). In Experiment 1, we report findings from Lewis rats 3 weeks after Complete Freund's adjuvant (CFA) injection into the knee joint (n = 16) compared with the controls (n = 14).
View Article and Find Full Text PDFSci Justice
September 2025
Department of Forensic Science, People's Public Security University of China, Beijing 100038, China. Electronic address:
As a critical frontier in forensic science, the profiling of physical evidence characteristics has garnered substantial attention. This study employed gas chromatography-mass spectrometry (GC-MS) to investigate age-related differences in sebaceous fingermark fatty acid compositions. Fingermark samples from 80 volunteers were analyzed to characterize fatty acid profiles across different age groups.
View Article and Find Full Text PDFPLoS One
September 2025
Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Polar protic and aprotic solvents can effectively simulate the maturation of breast carcinoma cells. Herein, the influence of polar protic solvents (water and ethanol) and aprotic solvents (acetone and DMSO) on the properties of 3-(dimethylaminomethyl)-5-nitroindole (DAMNI) was investigated using density functional theory (DFT) computations. Thermodynamic parameters retrieved from the vibrational analysis indicated that the DAMNI's entropy, heat capacity, and enthalpy increased with rising temperature.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China.
Objective: The incidence of inflammatory bowel disease (IBD) peaks between the ages of 15 and 40. This age range coincides with women of childbearing age (WCBA), who face unique challenges like adverse pregnancy outcomes and heightened anxiety. Despite the rising global prevalence of IBD, particularly among younger populations, the burden of IBD among women, especially WCBA, remains underexplored.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Gynecology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Background: Ovarian cancer remains the most lethal gynecological cancer, with fewer than 50% of patients surviving more than five years after diagnosis. This study aimed to analyze the global epidemiological trends of ovarian cancer from 1990 to 2021 and also project its prevalence to 2050, providing insights into these evolving patterns and helping health policymakers use healthcare resources more effectively.
Methods: This study comprehensively analyzes the original data related to ovarian cancer from the GBD 2021 database, employing a variety of methods including descriptive analysis, correlation analysis, age-period-cohort (APC) analysis, decomposition analysis, predictive analysis, frontier analysis, and health inequality analysis.