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College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Bacterial skin infections are common in dogs and often secondary to underlying conditions like allergies or ectoparasite infestations. Untreated primary causes can lead to recurrent infections and an increased risk of antimicrobial resistance, including methicillin-resistant (MRSP), posing a substantial clinical challenge. Here, we analyzed 896 canine bacterial skin infection samples collected from the China Agricultural University Veterinary Teaching Hospital between 2018 and 2022.
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Article Synopsis
- The study investigates the link between pyoderma gangrenosum (PG) and inflammatory bowel disease (IBD), highlighting that while the exact cause of their co-occurrence is unclear, there is evidence suggesting IBD increases the risk of PG.
- Researchers utilized genome-wide association study data to analyze the genetic relationship and potential mediating role of immune cells between the two conditions, employing various statistical techniques.
- The results indicated that IBD significantly raises the risk of PG, with specific types of IBD (ulcerative colitis and Crohn's disease) strongly correlating with this risk, and CD4 regulatory T cells playing a key mediating role in this interaction.