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Exploring therapeutic potential of Cannabis based therapy in autoimmune and rheumatic disorders.
Autoimmun Rev
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Department of Medicine 'B' & The Zabludowiz Center of Autoimmune diseases, Sheba Medical Center, Tel-Hashomer, Israel; Faculty of Medical and Health Sciences, Tel-Aviv University, Israel. Electronic address:
The medical use of cannabis is expanding across many countries, with some legalizing its use outright and others implementing medical licensure systems to approve treatment for eligible patients. Despite this growing interest and utilization, there remains a lack of solid scientific evidence supporting its medical use, even though cannabis has been used therapeutically for thousands of years. The goal of the following communication is to present updated data on the potential roles of cannabis-based treatments in various autoimmune and rheumatic conditions.
View Article and Find Full Text PDFTranscatheter aortic valve replacement for older patients with isolated aortic regurgitation.
J Geriatr Cardiol
July 2025
Aortic regurgitation (AR) poses distinct challenges in interventional cardiology, necessitating novel approaches for treatment. This editorial examined the evolving landscape of transcatheter aortic valve replacement (TAVR) as an alternative therapeutic strategy for AR, particularly in patients deemed high risk for surgery. We explored the anatomical and pathophysiological disparities between AR and aortic stenosis (AS) and elucidates the technical nuances of TAVR procedures in AR patients, emphasizing the need for precise prosthesis positioning and considerations for excessive stroke volume.
View Article and Find Full Text PDFThe multidisciplinary Heart Team in mitral valve transcatheter edge-to-edge repair.
Herz
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Medizinische Klinik und Poliklinik I, LMU Klinikum, LMU München, Munich, Germany.
Treatment options for mitral regurgitation (MR) have markedly evolved over the past few decades, with mitral valve transcatheter edge-to-edge repair (M-TEER) expanding the clinical armamentarium of guideline-directed medical therapy and surgical techniques. However, the variety of mitral valve anatomies, the presence of heart failure (HF), and consideration of the individual patient risk require a multidisciplinary Heart Team approach to identify the optimal treatment for MR for each patient. Despite the growing field of transcatheter mitral interventions and the longstanding availability of surgical mitral valve repair and replacement, evidence from randomized clinical trials comparing intervention with surgery remains scarce.
View Article and Find Full Text PDFExpanding the hybrid armamentarium for adult aortic coarctation with arch aneurysm.
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Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH.
The Extended Forehead Flap: Expanding the Armamentarium for Forehead and Anterior Scalp Reconstruction.
Isr Med Assoc J
August 2025
Department of Plastic Surgery, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel.
Background: The forehead and scalp play a crucial role in the aesthetic appearance of the face. Extensive oncological resections that result in significant defects create challenges for reconstruction and require various surgical techniques.
Objectives: To present the planning and surgical technique required for a simple, reproducible one-stage flap to reconstruct an extensive forehead defect.