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Background: With the increasing trend ofpopulation aging, erectile dysfunction (ED) among elderly men has emerged as apressing health concern. Despite extensive research on the relationship betweenED and aging, ongoing discoveries and evidence continue to arise.
Objective: Through this comprehensiveanalysis, we aim to provide a more nuanced theoretical framework for thedevelopment of preventive and therapeutic strategies for senile ED, ultimatelyenhancing the quality of life for elderly men.
Methods: This review delves deeper into thecore mechanisms underlying ED in the context of aging and offers acomprehensive overview of published meta-analyses and systematic reviewspertinent to these conditions.
Results And Conclusion: Our findings revealthat local structural damage to the penis, vascular dysfunction, neuronalinjury, hormonal alterations, other physiological changes, and psychologicalbarriers all play pivotal roles in the pathogenesis of aging-related ED. Furthermore, more than 20 diseases closely associated with aging have beenimplicated in the occurrence of ED, further compounding the complexity of thisissue.
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http://dx.doi.org/10.1111/andr.13778 | DOI Listing |
Int J Urol
September 2025
Department of Urology, National Defense Medical College, Saitama, Japan.
Objective: To investigate factors associated with persistent erectile dysfunction (ED) after delayed anastomotic urethroplasty (DAU) in patients with pelvic fracture urethral injury (PFUI).
Methods: This retrospective study included 57 sexually active male patients who underwent DAU between 2008 and 2023. Erectile function was assessed using the Sexual Health Inventory for Men (SHIM) questionnaire both preoperatively and at least 12 months postoperatively.
Arch Esp Urol
August 2025
Department of Urology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 214000 Wuxi, Jiangsu, China.
Background: A plethora of studies have demonstrated that the level of uric acid (UA) and gout are the risk factors for erectile dysfunction (ED). However, the causal effect of UA level and gout on ED is still unclear. This Mendelian randomization (MR) study aims to examine the bidirectional causality between ED and UA levels as well as gout.
View Article and Find Full Text PDFArch Esp Urol
August 2025
Department of Urology, National Taiwan University Hospital, 10002 Taipei, Taiwan.
Objective: Conventional penile venous surgery for erection restoration and surgery for penile augmentation have been controversial. Based on de novo penile fibrovascular assembly, we report innovative penile venous stripping (PVS) and factual penile girth enhancement (FPGE).
Methods: From 2013 to 2023, refractory impotence and dysmorphia prompted 31 patients to seek PVS and FPGE, and all of them were confirmed with veno-occlusive dysfunction.
Am J Physiol Regul Integr Comp Physiol
September 2025
Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
Cystathionine γ-lyase (CSE) produces hydrogen sulfide (HS), a vasodilator critical for vascular function. While its systemic effects are well-documented, its role in erectile physiology remains unclear. This study investigated the impact of CSE deletion on vascular and erectile tissue reactivity.
View Article and Find Full Text PDFFront Reprod Health
August 2025
Department of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Nigeria.
Background: Vitamin D, sometimes referred to as the "sunshine vitamin", is well-known for its role in maintaining bone health processes that are highly dependent on calcium regulation. However, there is an emerging wealth of evidence that this fat-soluble vitamin has an important role in male sexual health regarding erectile function, production of testosterone, and overall fertility. Due to the increased vitamin D deficiency rates in most populations, the implications of its deficiency on male sexual functions have gained great interest.
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