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Food Compass is a nutrient profiling system used to assess the healthfulness of diverse foods, beverages and meals. Here we present a revised version of Food Compass (Food Compass 2.0) incorporating new data on specific ingredients and the latest diet-health evidence. Food Compass 2.0 has been validated against health outcomes in a population from the United States and demonstrates enhanced ability to characterize foods and beverages based on their healthfulness.
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http://dx.doi.org/10.1038/s43016-024-01053-3 | DOI Listing |
CNS Drugs
August 2025
Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA.
Background And Objective: Viloxazine ER (extended-release capsules; Qelbree) is a nonstimulant medication that has been approved by the United States Food and Drug Administration (FDA) for treatment of pediatric and adult attention-deficit/hyperactivity disorder (ADHD). This phase 3, open-label extension (OLE) trial evaluated the long-term safety and efficacy of viloxazine ER in children and adolescents with ADHD.
Methods: Participants completing the phase 2 or one of the four phase 3 double-blind, placebo-controlled clinical trials were eligible for the OLE trial.
Microbiol Res
August 2025
Natural Resource Management and Sustainability Program, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkuntien, Bangkok 10150, Thailand; LigniTech-Lignin Technology Research Group, School of Bioresources and Technology, King Mongkut's University of Techn
Mycovirus infections significantly impact fungal virulence and physiology, inducing either hypovirulence or hypervirulence. This study investigated the hypovirulent effects of Colletotrichum gloeosporioides RNA virus 1 (CgRV1-Ssa-44.1) infection on Colletotrichum gloeosporioides using multi-omics approaches.
View Article and Find Full Text PDFJ Immunother Cancer
July 2025
Oncology Global Clinical Development, GSK, Baar, Switzerland.
Immune checkpoint inhibitors targeting negative regulatory checkpoints including programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 have produced significant improvements in progression-free survival (PFS) and overall survival in multiple solid tumors. Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly expressed by exhausted T cells. Dual blockade of LAG-3 and PD-1 with monoclonal antibodies relatlimab and nivolumab has improved PFS in advanced melanoma, leading to Food and Drug Administration approval for this indication.
View Article and Find Full Text PDFJAMIA Open
August 2025
Parkland Center for Clinical Innovation (PCCI), Dallas, TX 75247, United States.
Objectives: To determine whether a novel digital tool, the Community Vulnerability Compass (CVC), built using large datasets, can accurately measure neighborhood- and individual-level social determinants of health (SDOH) at scale. Existing SDOH indexes fall short of this dual requirement.
Materials And Methods: : A cross-sectional study by Parkland Health (Parkland) and Parkland Center for Clinical Innovation (PCCI) to design, build, deploy, and validate CVC in Dallas County/across Texas (2018-2024).