98%
921
2 minutes
20
This article traces the evolution of the Big Events framework since it began as an attempt to understand why sociopolitical transitions in the Former Soviet Union, South Africa, and Indonesia were followed by HIV outbreaks. Big Events frameworks have evolved over time, but all versions try to concretize how macrosocial changes lead to social, personal and environmental changes that shape risk environments and drug use or other behavioral patterns in ways that may lead to epidemics. Important stages in the evolution of the Big Events framework included understanding that the sequelae of Big Events were contingent rather than deterministic, and the development of new survey measures to understand pathways through which Big Events affect social and epidemiologic outcomes. On a broader level, the Big Events framework is a useful crystallization and application of more abstract sociological, social epidemiologic and Marxist frameworks about upstream/downstream relationships and how major social changes are related to epidemics. As such, they raise issues of how to conduct research on dialectical interaction processes. On another level, this article traces the Big Events "style of thought" as Mannheim (Mannheim, 1971) termed it, within the historical context of changes in public health and social science theory, particularly during and after the 1960s.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540725 | PMC |
http://dx.doi.org/10.1016/j.drugpo.2024.104606 | DOI Listing |
Clin Kidney J
September 2025
Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Background: Steroidal mineralocorticoid receptor antagonists (MRAs), including spironolactone, effectively treat resistant hypertension, reduce proteinuria and lower mortality in heart failure with reduced ejection fraction. However, their long-term effects in chronic kidney disease (CKD) remain unclear. This study investigated spironolactone's impact on end-stage renal disease (ESRD), major adverse cardiovascular events (MACE), hyperkalemia and mortality in CKD patients.
View Article and Find Full Text PDFJ Psychopathol Clin Sci
September 2025
Department of Psychology, University of Zurich.
Personality functioning, or Criterion A of the Alternative Model of Personality Disorders, captures deficits in intrapersonal and interpersonal capacities, is believed to be relatively malleable, and is associated with normal range personality (e.g., Big Five traits).
View Article and Find Full Text PDFDiscov Endocrinol Metab
August 2025
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722W 168th street, New York, NY 1109 USA.
Background And Aims: Urinary zinc has been associated with cardiometabolic endpoints, including diabetes and cardiovascular disease, but evidence for peripheral artery disease (PAD) is limited. We evaluated prospective associations between urinary zinc and incident PAD and amputation events in the Strong Heart Study (SHS), a large epidemiological cohort of American Indian adults in the United States.
Methods: A total of 2,045 PAD-free and 2,180 amputation-free participants were included at baseline (1989-91), (mean age 56 years, 61% female).
Zhongguo Zhong Yao Za Zhi
July 2025
China Military Institute of Chinese Materia, Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.
In recent years, there have been frequent adverse reactions/events associated with traditional Chinese medicine(TCM), especially liver injury related to traditional non-toxic TCM, which requires adequate attention. Liver injury related to traditional non-toxic TCM is characterized by its sporadic and insidious nature and is influenced by various factors, making its detection and identification challenging. There is an urgent need to develop a strategy and method for early detection and recognition of traditional non-toxic TCM-related liver injury.
View Article and Find Full Text PDFCommun Eng
September 2025
Department of Civil, Environmental and Geomatic Engineering, University College London, London, UK.
Conventional natural-hazard risk-modeling approaches do not consider possible unintended negative socioeconomic consequences of designing infrastructure expansions in a risk-informed way. Here, we propose a people-centered decision-making framework for urban infrastructure development that addresses this issue. The framework integrates a bespoke agent-based model that accounts for implications of variations in infrastructure expansion on dynamic land values and related residential location decision making.
View Article and Find Full Text PDF