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Typically developing infants, between the corrected age of 9-20 weeks, produce fidgety movements. These movements can be identified with the General Movement Assessment, but their identification requires trained professionals to conduct the assessment from video recordings. Since trained professionals are expensive and their demand may be higher than their availability, computer vision-based solutions have been developed to assist practitioners. However, most solutions to date treat the problem as a direct mapping from video to infant status, without modeling fidgety movements throughout the video. To address that, we propose to directly model infants' short movements and classify them as fidgety or non-fidgety. In this way, we model the explanatory factor behind the infant's status and improve model interpretability. The issue with our proposal is that labels for an infant's short movements are not available, which precludes us to train such a model. We overcome this issue with active learning. Active learning is a framework that minimizes the amount of labeled data required to train a model, by only labeling examples that are considered "informative" to the model. The assumption is that a model trained on informative examples reaches a higher performance level than a model trained with randomly selected examples. We validate our framework by modeling the movements of infants' hips on two representative cohorts: typically developing and at-risk infants. Our results show that active learning is suitable to our problem and that it works adequately even when the models are trained with labels provided by a novice annotator.
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http://dx.doi.org/10.1109/JBHI.2024.3473947 | DOI Listing |
Cell Rep Methods
August 2025
Interdepartmental Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06511, USA; Department of Biostatistics, Yale University, New Haven, CT 06511, USA. Electronic address:
Single-cell multi-modal data integration has been an area of active research in recent years. However, it is difficult to unify the integration process of different omics in a pipeline and evaluate the contributions of data integration. In this article, we revisit the definition and contributions of multi-modal data integration and propose a strong and scalable method based on probabilistic deep learning with an explainable framework powered by statistical modeling to extract meaningful information after data integration.
View Article and Find Full Text PDFJ Hazard Mater
August 2025
Department of Environmental Science, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea; Interdisciplinary Program in Earth Environmental System Science & Engineering, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea; Gangwon particle pollution res
This study evaluates the oxidative potential (OP) of PM and its chemical drivers across three contrasting environments in South Korea: a residential area, a cement factory, and a charcoal kiln facility. Mass-normalized OP (OPm, reflecting intrinsic particle reactivity) ranged from 9.5 to 13.
View Article and Find Full Text PDFPhytomedicine
August 2025
Key Laboratory of Emergency and Trauma of Ministry of Education, Engineering Research Center for Hainan Biological Sample Resources of Major Diseases, the Hainan Branch of National Clinical Research Center for Cancer, the First Affiliated Hospital, Hainan Medical University, Haikou 571199, China; Ke
Background: Traditional Chinese medicine (TCM) has shown anti-tumor potential, but its molecular mechanisms remain poorly understood. This integrated bioinformatics, network pharmacology, and experimental study investigated the anti-cancer effects and mechanisms of Dendrobin A, a pharmacologically active bibenzyl compound from Dendrobium nobile, in gastric cancer (GC).
Methods: Differentially expressed genes (DEGs) were identified through analysis of the TCGA-STAD dataset.
Anal Chem
September 2025
Anhui Key Laboratory of Biomedical Materials and Chemical Measurement, Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P.R. China.
Current colorimetric sensing arrays for antioxidant detection often struggle with discrimination due to cross-reactive signals from individual nanozymes. These signals are typically modulated by external factors such as pH or chromogenic substrates, offering limited kinetic and mechanistic diversity. To overcome this, we present a novel triple-channel colorimetric sensing array utilizing two distinct single-atom nanozymes (Cu SA and Fe SA) and one dual-atom nanozyme (CuFe DA).
View Article and Find Full Text PDFMetab Brain Dis
September 2025
Taihe Hospital of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Fuyang, 236607, Anhui, China.
The therapeutic mechanisms of Shenwu Yizhi Capsule (SWYZC), a widely used treatment for vascular dementia (VD), remain unclear. This study integrated network pharmacology and experimental methods to elucidate the effects and mechanisms of SWYZC on cognitive function in VD rats. A VD model was established via bilateral common carotid artery occlusion (2-VO).
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