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Article Abstract
This Editorial introduces and contextualizes the papers of the Virtual Special Issue: Advancing the Cryopreservation of Cells, Tissues and Organs Using Model Biological Systems.
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| http://dx.doi.org/10.1016/j.cryobiol.2024.104975 | DOI Listing |
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Profiling the metabolome of adenomyosis-associated infertility patients to predict the pregnancy outcome of frozen embryo transfer.
Front Endocrinol (Lausanne)
September 2025
State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University, Third Hospital, Beijing, China.
Objective: This study explores the metabolic profiles in the peripheral blood of infertile patients with adenomyosis (ADM) to identify key metabolites affecting pregnancy outcomes in these patients undergoing frozen embryo transfer (FET). Our goal is to create a metabolite-based clinical prediction model for pregnancy outcomes in adenomyosis-associated infertility.
Methods: This prospective cohort study from the Reproductive Center at Peking University Third Hospital enrolled 94 infertile patients with adenomyosis and control (CTRL) patients undergoing FET.
Unveiling the Balkans' advances: biotechnology of woody plants in the early 21 century.
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Fruit Research Institute, Čačak, Serbia.
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View Article and Find Full Text PDFFrozen potential: embryo research at the crossroads of ethics, regulation and scientific opportunity.
Development
September 2025
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
In an era of expanding reproductive possibilities, the human embryo has come to represent both immense potential and profound constraint. Advances in medically assisted reproduction (MAR) have led to the cryopreservation of hundreds of thousands of embryos each year, yet many remain unused and are ultimately discarded. Meanwhile, studies aimed at understanding infertility, early human development and preventing miscarriage continue to face significant barriers, with only a small fraction of embryos ever donated to research.
View Article and Find Full Text PDFThe mechanism of heat stress-induced injury in the immature oocytes of zebrafish (Danio rerio).
J Reprod Dev
September 2025
Laboratory of Animal Science, College of Agriculture and Marine Science, Kochi University, Kochi 783-8502, Japan.
Immature zebrafish oocytes are highly susceptible to high temperatures, making it difficult to warm cryopreserved oocytes rapidly. In the present study, we aimed to investigate whether thermosensitive channels, lipid mediators, and ferroptosis are involved in heat stress-induced injury in immature zebrafish oocytes. Oocytes were injected with inhibitors of a heat-sensitive channel (TRPV1) and multiple enzymes-cytosolic phospholipase Aα (cPLAα), cyclooxygenases (COXs), arachidonate lipoxygenase 5 (ALOX5), and lysophosphatidylcholine acyltransferase 2 (LPCAT2).
View Article and Find Full Text PDFStudy Question: Can patient age and ovarian reserve tests predict the number of cryopreserved oocytes in patients undergoing one or more ovarian stimulation cycles for elective oocyte cryopreservation (EOC)?
Summary Answer: A predictive model incorporating patient age, antral follicle count (AFC), anti-Müllerian hormone (AMH), and FSH levels achieved the greatest predictive accuracy.
What Is Known Already: As a consequence of societal evolution, women are increasingly delaying starting a family. However, the natural decline in ovarian reserve and oocyte quality as age advances can increase the risk of age-related fertility decline (ARFD) and involuntary childlessness.