Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Nuclear overhauser enhancement is a confounding factor arising from the in vivo application of a chemical exchange saturation transfer technique in which two nuclei in close proximity undergo dipole cross-relaxation. Several studies have shown applicability and efficacy of nuclear overhauser enhancement in observing tumors and other lesions in vivo. Thus, this effect could become an emerging molecular imaging research tool for many diseases. Moreover, nuclear overhauser enhancement has the advantages of simplicity, noninvasiveness, and high resolution and has become a major focus of current research. In this review, we summarize the principles and applications of nuclear overhauser enhancement. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 1.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmri.29623 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Zero-Field Overhauser Dynamic Nuclear Polarization.
ACS Omega
August 2025
Quantum Magnetic Sensing Group, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea.
Overhauser dynamic nuclear polarization (O-DNP) enables the production of hyperpolarization in liquids via the dissolution of nitroxide radicals. However, the application of magnetic fields has been inevitable. In the present study, we experimentally demonstrate that water can be hyperpolarized through O-DNP at effectively zero magnetic field.
View Article and Find Full Text PDFNovel transferrin receptor-mediated enzyme replacement therapy efficiently treats myogenic and neurogenic aspects of Pompe disease in mice.
Mol Ther Methods Clin Dev
September 2025
Sanofi, Rare and Neurologic Disease Research TA, Cambridge, MA 02141, USA.
Pompe disease (PD) is a multisystemic progressive disease caused by acid-alpha glucosidase (GAA) deficiency. Patients display a spectrum of phenotypes ranging from the severe, rapidly progressive infantile-onset PD (IOPD) form to the slower progressing late-onset PD (LOPD). Enzyme replacement therapies (ERTs) are the only approved treatments; they decrease mortality in IOPD while maintaining or improving motor and respiratory function in LOPD.
View Article and Find Full Text PDFSensitive Detection of Dendritic Lithium Morphologies by Dynamic Nuclear Polarization.
J Phys Chem Lett
August 2025
Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot 761000, Israel.
Lithium metal batteries are a promising energy storage technology, but their commercialization is hindered by nonuniform lithium deposition, which is detrimental to the battery lifetime and safety. In particular, needle-like dendrites pose the greatest risk as they often lead to short-circuits; as such, it is essential to identify and mitigate their formation for enabling use of lithium metal anodes. Here we demonstrate that Overhauser dynamic nuclear polarization (DNP)- enhanced NMR, where the high polarization of the lithium conduction electrons increases the sensitivity of lithium NMR, is a powerful tool for determining the lithium morphology.
View Article and Find Full Text PDFEvaluating the effectiveness of distortion self-correction for CEST-EPI.
Magn Reson Med
August 2025
Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Purpose: EPI is a fast acquisition sequence, but suffers from geometric distortion because of B field inhomogeneity. This study aims to evaluate the effectiveness of using ΔB map generated from single-shot CEST-EPI to achieve distortion self-correction (DISC).
Methods: CEST MRI usually requires B correction during postprocessing, and the ΔB map can be calculated directly from Z-spectra without extra scan.
Solution-like Water Transport Across Molecular to Macroscopic Length Scales in Crosslinked Poly(ethylene glycol diacrylate) Networks with Tailored Sidechains.
J Polym Sci (2020)
August 2025
Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106-5080; Department of Chemistry & Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106-9510; Department of Chemistry, Northwestern University, Evanston, IL, 60208.
Poly(ethylene glycol) (PEG)-based materials, like PEG-diacrylate (PEGDA), are prized for their hydrophilic, inert properties, and leveraged in hydrogels and as membrane mimics. While network chemistry is often tuned for selective transport and antifouling, fundamental understanding of water dynamics at the network surface and impact on bulk transport is limited. We utilize Overhauser dynamic nuclear polarization (ODNP) to measure nanoscale water diffusivity near a tethered spin label at the water-polymer surface and compare to bulk water diffusivity from pulsed field gradient (PFG) NMR.
View Article and Find Full Text PDF