Time will tell: Employing long-term normothermic machine perfusion to gain new insight into bile duct regeneration.

Am J Transplant

Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; National Institute of Health Research (NIHR) Blood and Transplant Research

Published: January 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajt.2024.09.024DOI Listing

Publication Analysis

Top Keywords

time will
4
will employing
4
employing long-term
4
long-term normothermic
4
normothermic machine
4
machine perfusion
4
perfusion gain
4
gain insight
4
insight bile
4
bile duct
4

Similar Publications

Background: Diabetic foot ulcers (DFUs) are a major clinical challenge, particularly among patients with refractory ulcers, that often lead to severe complications such as infection, amputation, and high mortality. Innovations supported by strong clinical evidence have the potential to improve healing outcomes, enhance quality of life, and reduce the economic burden on individuals and health care systems.

Objective: To describe the design of the concurrent optical and magnetic stimulation (COMS) therapy Investigational Device Exemption (IDE) study for refractory DFUs (MAVERICKS) trial.

View Article and Find Full Text PDF

To develop and validate a deep-learning-based algorithm for automatic identification of anatomical landmarks and calculating femoral and tibial version angles (FTT angles) on lower-extremity CT scans. In this IRB-approved, retrospective study, lower-extremity CT scans from 270 adult patients (median age, 69 years; female to male ratio, 235:35) were analyzed. CT data were preprocessed using contrast-limited adaptive histogram equalization and RGB superposition to enhance tissue boundary distinction.

View Article and Find Full Text PDF

Metagenomic complexity of high, seasonal transmission of Plasmodium spp. in asymptomatic carriers in Northern Sahelian Ghana.

Commun Med (Lond)

September 2025

Department of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Background: Mixed-species, mixed-strain plasmodia infections are known to occur in humans in malaria endemic areas. It may be surprising that to date, the extent of this complexity has not been systematically explored in high-burden countries of sub-Saharan Africa, especially in the reservoir of asymptomatic infections in all ages, which sustains transmission.

Methods: Here we take a metagenomic lens to these infections by sampling variable blood volumes from 188 afebrile residents living in high, seasonal transmission in Northern Sahelian Ghana.

View Article and Find Full Text PDF

Introduction: Drowsiness is a significant cause of crashes in the various transport industries, including automotive, aviation, and rail. Our previous study investigated the differential induction of drowsiness in drivers caused by specific whole-body vibration (WBV) frequency ranges, with an amplitude of 0.2 m/s r.

View Article and Find Full Text PDF

Introduction: Nipah virus (NiV) is a bat-transmitted paramyxovirus causing recurrent, high-mortality outbreaks in South and South-East Asia. As a WHO priority pathogen, efforts are underway to develop therapies like monoclonal antibodies and small-molecule antivirals, which require evaluation in clinical trials. However, trial design is challenging due to limited understanding of NiV's clinical characteristics.

View Article and Find Full Text PDF