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Article Abstract
Objectives: To validate the feasibility of one-stop 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) and [Ga]Ga-fibroblast activation protein inhibitor-04 ([Ga]Ga-FAPI-04) dual-low-activity-tracer positron emission tomography/computed tomography (PET/CT) at 34 min post-injection of [Ga]Ga-FAPI-04 and explore its additional value.
Methods: Thirty pairs of patients with suspected malignancies who underwent dual-tracer imaging were enrolled in this retrospective study. The images were reconstructed at 34-39 and 50-60 min after additional injection of [Ga]Ga-FAPI-04 (in one-stop FDG-FAPI PET/CT, named PET, PET, and PET; in the 2-day protocol, named PET, PET, and PET, respectively). Tumour-to-normal ratios (TNR) of lesions in PET, PET, and PET and TNR of lesions in PET and PET were evaluated separately. To evaluate the potential added value of one-stop FDG-FAPI PET/CT over the 2-day protocol, TNRs of PET, PET, and PET were compared with PET. The lesion detectability of the two imaging protocols was evaluated by chi-square test.
Results: Comparing FAPI-weighted PET (PET and PET) and single-tracer imaging (PET) in one-stop FDG-FAPI PET/CT, TNRs of FAPI-weighted PET were higher than those of PET. PET and PET showed similar performance in lesion detectability and TNRs (all P > 0.05). In the 2-day protocol, there are no statistically significant differences in TNRs of all lesions at PET and PET. Comparing one-stop FDG-FAPI PET/CT with the 2-day protocol, TNRs of PET were significantly higher than those of PET but lower than those of PET and PET. Lesion detectability in the one-stop FDG-FAPI PET/CT was higher than that in the 2-day protocol. The average radiation dose in one-stop FDG-FAPI PET/CT was significantly lower than that in the 2-day protocol (P<0.001).
Conclusion: One-stop FDG-FAPI PET/CT at 34 min could provide sufficient information to meet clinical diagnosis and showed better lesion detectability than that in the 2-day protocol.
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