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http://dx.doi.org/10.1183/23120541.00433-2024 | DOI Listing |
World J Clin Oncol
August 2025
Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India.
Background: Low rectal cancer poses a significant surgical challenge because of its close proximity to the anal sphincter, often requiring radical resection with permanent colostomy to achieve oncological safety. Revisited rectal anatomy, advances in surgical techniques and neoadjuvant therapies have enabled the possibility of sphincter-preserving procedures, however, it is uniformly not applicable. Selecting appropriate candidates for sphincter preservation is crucial, as an ill-advised approach may compromise oncological outcome or lead to poor functional outcomes.
View Article and Find Full Text PDFThis study explored the differences in circulating cytokines between sexes and age and their association with the pathogenesis of coronary artery disease ( CAD ) in order to identify populations suitable for anti-inflammatory treatment. Methods:This retrospective study included hospitalized patients who underwent coronary angiography between October 2022 and November 2024. The selected participants were grouped by age and sex to compare differences in circulating inflammatory cytokine levels and CAD occurrence.
View Article and Find Full Text PDFThe main limitations of cancer treatment with high doses of recombinant interleukin 2 (IL-2) are high toxicity and the undesired expansion of regulatory T cells. The generation of IL-2 mutated variants (muteins) with changes in the affinity for different chains of the IL-2 receptor (IL-2R) allows selective stimulation of effector cells while overcoming its toxicity. As increasing the IL-2 affinity for the IL-2R beta chain leads to better antitumor effect, we generated a group of these muteins using phage display technology, in a previous work.
View Article and Find Full Text PDFJ Inflamm Res
August 2025
Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
Objective: Recurrent pericarditis (RP) is a rare cardiac condition characterized by recurrent inflammation, in which interleukin-1 (IL-1) is a key mediator. Despite increasing use of IL-1 inhibitors, comprehensive evaluations of rilonacept for RP are very limited, especially in China, where RP was newly listed as a rare disease in 2023. This review addresses the current gap by systematically assessing the efficacy, safety, cost-effectiveness, innovativeness, suitability, and accessibility of rilonacept in the management of RP, providing evidence-based guidance for clinical practice.
View Article and Find Full Text PDFJMIR Form Res
August 2025
Centre for Digital Health Interventions, ETH Zurich, Zurich, Switzerland.
Background: Accurate and accessible measurements of inflammatory biomarkers are crucial for the diagnosis and monitoring of inflammatory diseases. The gold-standard C-reactive protein (CRP) requires venipuncture, which, despite providing high-quality samples, can cause discomfort, anxiety, and pain, particularly in vulnerable populations such as older patients. It is also resource-intensive, is unsuitable for remote or at-home use, and lacks continuous monitoring capability.
View Article and Find Full Text PDF