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Heat is associated with increased risk of morbidity and mortality. People who are incarcerated are especially vulnerable to heat exposure due to demographic characteristics and their conditions of confinement. Evaluating heat exposure in prisons, and the characteristics of exposed populations and prisons, can elucidate prison-level risk to heat exposure. We leveraged a high-resolution air temperature data set to evaluate short and long-term patterns of heat metrics for 1,614 prisons in the United States from 1990 to 2023. We found that the most heat-exposed facilities and states were mostly in the Southwestern United States, while the prisons with the highest temperature anomalies from the historical record were in the Pacific Northwest, the Northeast, Texas, and parts of the Midwest. Prisons in the Pacific Northwest, the Northeast, and upper Midwest had the highest occurrences of days associated with an increased risk of heat-related mortality. We also estimated differences in heat exposure at prisons by facility and individual-level characteristics. We found higher proportions of non-white and Hispanic populations in the prisons with higher heat exposure. Lastly, we found that heat exposure was higher in prisons with any of nine facility-level characteristics that may modify risk to heat. This study brings together distinct measures of exposure, vulnerability, and risk, which would each inform unique strategies for heat-interventions. Community leaders and policymakers should carefully consider which measures they want to apply, and include the voices of directly impacted people, as the differing metrics and perspectives will have implications for who is included in fights for environmental justice.
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http://dx.doi.org/10.1029/2024GH001108 | DOI Listing |
Int J Nanomedicine
September 2025
Department of Ultrasonic Imaging, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
Background: Due to the complex structure and variable microenvironment in the progression of bladder cancer, the efficacy of traditional treatment methods such as surgery and chemotherapy is limited. Tumor residual, recurrence and metastasis are still difficult to treat. The integration of diagnosis and treatment based on nanoparticles can offer the potential for precise tumor localization and real-time therapeutic monitoring.
View Article and Find Full Text PDFCureus
August 2025
Vascular Surgery, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Background Fasting during the month of Ramadan is practiced by over a billion Muslims worldwide. This religious observance, which involves complete abstention from food and fluids during daylight hours, may contribute to dehydration and increase the risk of venous thromboembolism (VTE), particularly in hot climates. Despite this theoretical concern, limited clinical evidence exists on the actual incidence and risk of VTE associated with prolonged fasting.
View Article and Find Full Text PDFPhysiol Plant
September 2025
Centre of Molecular and Environmental Biology (CBMA), Department of Biology, School of Sciences of the University of Minho, Braga, Portugal.
The Mediterranean Basin, a hotspot for tomato production, is one of the most vulnerable areas to climate change, where rising temperatures and increasing soil and water salinization represent major threats to agricultural sustainability. Thus, to understand the molecular mechanisms behind plant responses to this stress combination, an RNA-Seq analysis was conducted on roots and shoots of tomato plants exposed to salt (100 mM NaCl) and/or heat (42°C, 4 h each day) stress for 21 days. The analysis identified over 8000 differentially expressed genes (DEGs) under combined stress conditions, with 1716 DEGs in roots and 2665 in shoots being exclusively modulated in response to this specific stress condition.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
September 2025
Biochemistry and Phytochemistry Research Division, Jubilee Centre for Medical Research, Thrissur, Kerala, 680005, India. Electronic address:
7-Ketocholesterol (7-KC) is a biologically active oxysterol formed through the oxidation of cholesterol, predominantly under conditions of oxidative stress. It is generated both enzymatically in specific tissues such as the brain and liver, and non-enzymatically via reactive oxygen species (ROS), especially in aging tissues and heat-processed animal-derived foods. 7-KC exerts multifaceted effects on human health, extending beyond lipid metabolism to disrupt glucose and amino acid utilization, impair mitochondrial function, and provoke endoplasmic reticulum (ER) stress.
View Article and Find Full Text PDFEnviron Res
September 2025
School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Climate change has heightened awareness of the health impacts of non-optimal temperatures (cold and heat), including the effect of gestational exposure and birth outcomes. However, temperature exposure assessment remains methodologically challenging due to unaccounted individual spatiotemporal mobility and adaptive behaviors, a gap that has not been adequately addressed in published studies. Using data from a prospective birth cohort in Guangzhou, China, conducted from 2017 to 2020, we assessed and compared three different exposure measures: home-based exposure, derived solely from ambient temperature data at residential locations; mobility-based exposure, incorporating individuals' spatiotemporal activities to capture dynamic environmental conditions; and AC & mobility-based exposure, an extension of the mobility-based approach that further integrates data on air-conditioning usage.
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