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http://dx.doi.org/10.1007/s00134-024-07654-7 | DOI Listing |
Transplant Cell Ther
September 2025
Division of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Background: Pediatric patients undergoing hematopoietic stem cell transplant (HSCT) are at high risk for fungal infections including Candida, Aspergillus, and Mucorales necessitating the use of broad-spectrum antifungal agents such as posaconazole for prophylaxis and at times for treatment of invasive fungal infections. When first approved, posaconazole was limited to an immediate release oral suspension, which exhibited unreliable absorption dependent on co-administration with high fat meals. During HSCT, patients commonly have significant nausea, vomiting, and decreased enteral intake making this formulation particularly challenging.
View Article and Find Full Text PDFEur J Med Chem
August 2025
Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
Vector-borne parasitic diseases (VBPDs) represent a major global public health concern, with human African trypanosomiasis (HAT), Chagas disease, leishmaniasis, and malaria collectively threatening millions of people, particularly in developing regions. Climate change may further influence their transmission and geographic spread, increasing the global burden. As drug resistance continues to rise, there is an urgent need for novel therapeutic agents to expand treatment options and limit disease progression.
View Article and Find Full Text PDFChem Biodivers
September 2025
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University Sub Campus, Dharashiv, India.
The present study aims to develop novel antimalarial and antimicrobial agents by synthesizing a series of 25 triazolyl quinoline carboxylate derivatives via azide-alkyne 1,3-dipolar cycloaddition, starting from isatin and p-fluoroacetophenone. Structural characterization was performed using IR, H NMR, C NMR, and mass spectrometry. The synthesized hybrids were evaluated for their in vitro antimalarial activity against the chloroquine-sensitive Plasmodium falciparum 3D7 strain.
View Article and Find Full Text PDFJ Virol
September 2025
Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Bourbon virus (BRBV) is an emerging tick-borne virus that can cause severe and fatal disease in humans. BRBV is vectored via the tick, which is widely distributed throughout the central, eastern, and southern United States. Serosurveillance studies in Missouri and North Carolina identified BRBV-neutralizing antibodies in approximately 0.
View Article and Find Full Text PDFCureus
August 2025
Obstetrics and Gynaecology, Whittington Health National Health Service (NHS) Trust, London, GBR.
Hematometra is an uncommon and delayed complication following the surgical management of miscarriage. When it occurs in the early postoperative period, it is sometimes referred to as "Redo syndrome". We present the case of a 39-year-old woman who developed this rare condition following a suction and evacuation procedure performed for a missed miscarriage.
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