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One species-general life history (LH) principle posits that challenging childhood environments are coupled with a fast or faster LH strategy and associated behaviors, while secure and stable childhood environments foster behaviors conducive to a slow or slower LH strategy. This coupling between environments and LH strategies is based on the assumption that individuals' internal traits and states are independent of their external surroundings. In reality, individuals respond to external environmental conditions in alignment with their intrinsic vitality, encompassing both physical and mental states. The present study investigated attachment as an internal mental state, examining its role in mediating and moderating the association between external environmental adversity and fast LH strategies. A sample of 1169 adolescents (51% girls) from 9 countries was tracked over 10 years, starting from age 8. The results confirm both mediation and moderation and, for moderation, secure attachment nullified and insecure attachment maintained the environment-LH coupling. These findings suggest that attachment could act as an internal regulator, disrupting the contingent coupling between environmental adversity and a faster pace of life, consequently decelerating human LH.
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http://dx.doi.org/10.1017/S0954579424001500 | DOI Listing |
Prog Neuropsychopharmacol Biol Psychiatry
September 2025
Department of Women's and Children's Health, SciLifeLab, Uppsala University, Sweden. Electronic address:
Estrogens are suggested to affect mood by binding to widespread estrogen receptors in the brain and therewith modulating a variety of neurosignaling pathways. Single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptors might influence these actions and thereby play a role in the genetic foundation of mood disorders. Several SNPs in the estrogen receptor 1 (ESR1) gene have been studied in relation to anxiety and depression, while confounders and interaction with psychosocial factors have largely been overlooked.
View Article and Find Full Text PDFCell Rep
September 2025
Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:
An adverse gestational environment is a risk factor for the development of psychiatric disorders. Although studies have implicated modifications in neuronal DNA and chromatin, how these changes come about and lead to abnormal behaviors is not known. We sought to identify persistent DNA/chromatin and transcriptomic signatures induced by a proinflammatory gestational environment in the ventral dentate gyrus (vDG), a hippocampal region linked to anxiety.
View Article and Find Full Text PDFJ Affect Disord
September 2025
School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Urban Systems Institute, The University of Hong Kong, Hong Kong. Electronic address:
Background: Globally, childhood neglect remains common in both developed and developing settings. However, there is a lack of robust evidence regarding the association between childhood neglect and adult mental disorders.
Methods: Using a sibling-comparison study nested within the FAMILY Cohort, we assessed the role of childhood neglect and abuse in adult mental disorders, taking into account known and unknown familial confounders shared by siblings.
Clin Gastroenterol Hepatol
August 2025
Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles; Goodman Luskin Microbiome Center, University of California, Los Angeles; G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles; David Geffen School of Me
Background: Despite significant advances in the understanding of the pathogenesis of obesity and influencing factors, its prevalence continues to increase at an alarming rate. Social determinants of health (SDOH) encompass a broad range of psychosocial and environmental factors, including economic stability, education, access to healthcare, social support, isolation, neighborhood disadvantage, discrimination, early life adversity, and stress, all of which have been recognized to significantly increase the risk of obesity.
Aim: This review aims to elucidate the intricate relationship between SDOH and biological mechanisms related to the brain-gut-microbiome (BGM) system that lead to altered eating behaviors and obesity.
PLoS One
September 2025
Department of Neuroscience, University of Arizona, Tucson, Arizona, United States of America.
Understanding how genetic variability shapes responses to environmental and developmental factors is critical for advancing translational neuroscience. However, most preclinical studies rely on inbred mouse strains that do not capture the genetic complexity of human populations. One key area of translational research focuses on identifying the neural and behavioral consequences of early life trauma.
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