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Article Abstract
Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414743 | PMC |
| http://dx.doi.org/10.1039/d4ra05007j | DOI Listing |
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