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Article Abstract
Background And Objectives: is the second most common species causing infectious diseases and can lead to biofilm resistance. This study aims to adjust and synthesize a liposomal compound of and evaluate its antifungal properties against isolates.
Materials And Methods: The liposomal formulation of was optimized through the utilization of transmission electron microscopy (TEM), particle size analysis, zeta potential measurement, and UV-visible spectrophotometry. Furthermore, an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay was conducted on peripheral blood mononuclear cells (PBMCs). The antifungal efficacy was evaluated in accordance with the M27-A3 guideline.
Results: The minimum inhibitory concentrations (MICs) of oil and the liposomal formulation on isolates ranged from 128 to 8 µg/mL and from 250 to 31.25 µg/mL, respectively. The MIC and MIC values of oil and the liposomal formulation were 125, 187, and 32, 96 µg/mL, respectively. The viability percentage of cells treated with the liposomal formulation and free oil was 91% and 85%, respectively.
Conclusion: The cytotoxicity of free was significantly reduced when using nanoliposomes. The liposomal form of showed greater antifungal properties compared to the free extract against isolates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389775 | PMC |
| http://dx.doi.org/10.18502/ijm.v16i4.16316 | DOI Listing |
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