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Despite the gradual development of students' sedentary habits and associated health problems, only a few studies have extensively and systematically measured campus built environments (CBE) and their impact on street walking activity. This study explores the association between CBEs and pedestrian volume (PV). Comprehensive questionnaires, field audits, and GIS were used to measure the CBE variables and PV of 892 street segments on eight Chinese campuses in Tianjin. We used negative binomial regression models without spatial autocorrelations to investigate the relationship between the CBEs and PV. The findings indicated that campus Walk Score, facility and residential land ratio, campus design qualities, sidewalk conditions, street amenities, and other streetscape features were positively associated with PV. This study presents implications for campus research and planning practices in designing a pedestrian-friendly, sustainable, and healthy campus.
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http://dx.doi.org/10.1038/s41598-024-69881-8 | DOI Listing |
Front Biosci (Landmark Ed)
August 2025
Department of Neurology, The First Affiliated Hospital, Fujian Medical University, 350005 Fuzhou, Fujian, China.
Background: Glioblastoma (GBM) is an extremely aggressive brain tumor, marked by restricted therapeutic possibilities and a generally unfavorable prognosis. GBM's complexity and heterogeneity necessitate comprehensive genetic and immunological profiling to enhance therapeutic strategies.
Methods: The study integrated The Cancer Genome Atlas (TCGA) and Integrative Epidemiology Unit Open Genome-Wide Association Studies (IEU OpenGWAS) data to identify genetic factors influencing GBM using expression quantitative trait loci (eQTL) and genome-wide association studies (GWAS).
Aging Cell
September 2025
CREEC/CANECEV, MIVEGEC (CREES) Department, University of Montpellier, CNRS, IRD, Montpellier, France.
Aging, and by extension age-related diseases, has traditionally been understood through classical evolutionary genetic models, such as the mutation accumulation and antagonistic pleiotropy theories. However, these frameworks primarily focus on the declining efficacy of organismal-level selection against mutations with deleterious effects in late life. Here, we propose a novel hypothesis: many chronic diseases associated with aging may emerge, at least in part, as a result of selection acting at lower organizational levels, including non-replicative biological entities, enabled by the relaxation of selective pressures that constrained within-organism evolutionary processes in early life.
View Article and Find Full Text PDFJ Physician Assist Educ
September 2025
Jacqueline Sivahop, EdD, MS, PA-C, is an associate professor of Pediatrics, Child Health Associate/Physician Assistant Program, at University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Over the past decade, there has been a robust increase in the number of Physician Assistant/Associate (PA) Programs operating in the United States. Curriculum design and construction remains a major activity and strategic priority for our profession as PA education faculty. However, our curriculum design, redesign, and renewal initiatives are often focused on unique and idiosyncratic changes or "tinkering" that can lead to curriculum dilution and drift.
View Article and Find Full Text PDFJ Radiol Prot
September 2025
Welding Engineering R&D Team, Hanwha Ocean Co Ltd, 3370, Geoje-daero, Harmony Center 4th Floor, 3370 Geoje-daero, Geoje, Gyeongsangnam-do, 53302, Korea (the Republic of).
Radiographic testing (RT) is a critical non-destructive testing (NDT) method for ensuring the structural integrity of pipe welds through quantitative detection of internal defects. However, radiation safety concerns often lead to overly conservative regulatory restrictions, particularly affecting open-ceiling radiographic facilities through excessive limitations on irradiation direction and shielding, thereby reducing productivity. This study conducted quantitative analyses and on-site radiation measurements under varying irradiation angles and shielding conditions in an open-ceiling RT facility located within a pipe fabrication workshop.
View Article and Find Full Text PDFCryobiology
September 2025
UCIBIO - Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University Lisbon, Caparica, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, School of Science and Technology, NOVA University Lisbon, Caparica, Portugal. Electroni
High-throughput experimental screening is desirable to minimize data acquisition time from vast workloads. Cell cryopreservation experiments are routinely performed in single-sample cryovials despite cell seeding being performed in 96-well microplates because these substrates are known to induce microliter supercooling, are prone to thermal compressibility and their lengthy preparation period extends cell exposure time to potentially cytotoxic cryoprotectants. Rather than improving the methodological preciseness of cooling, latest efforts have focused on refining cryoprotectant formulations and supplement precautionary ice nucleators.
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