Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Extracellular vesicles play an important role in the progression of pancreatic adenocarcinoma (PAAD) through the transfer of proteins, mRNAs, and long noncoding RNAs (lncRNAs). However, the intricate interplay between extracellular vesicles-related lncRNAs and the tumor microenvironment (TME) remains poorly elucidated. Consequently, our investigation aimed to delineate the association between extracellular vesicles-related lncRNAs and the PAAD microenvironment. Initially, we identified differentially expressed lncRNAs (DELs) from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) project datasets. Subsequently, we validated the expression of these DELs within extracellular vesicles and assessed their prognostic implications in PAAD using the GSE133684 and TCGA datasets. Multiomics data were analyzed comprehensively, including genomic landscape, functional annotation, immune profiles, and therapeutic responses. Differential expression of selected lncRNAs in both cellular and exosomal fractions of PAAD was further confirmed through quantitative polymerase chain reaction (qPCR). Eight DELs were identified from TCGA and GTEx datasets, and two exosomal lncRNAs exhibited a significant correlation with overall survival, warranting further investigation. Specifically, elevated expression of LINC00996 correlated positively with immune infiltration and enhanced response to immunotherapy. Conversely, heightened expression of TRHED-AS1 was associated with compromised immune cell infiltration and diminished responsiveness to immunotherapy. Our study establishes a compelling link between two extracellular vesicles-related gene signatures, prognosis, and immune infiltration in PAAD. Notably, these signatures serve as robust prognostic indicators for PAAD patients, offering valuable insights for the strategic selection of immunotherapeutic interventions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366062 | PMC |
| http://dx.doi.org/10.1155/2024/2825971 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Exosomes Derived From Eutopic Endometrial Cells in Endometriosis and the Discovery of Related Serum miRNA Biomarkers for Endometriosis.
Am J Reprod Immunol
September 2025
Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Objective: Exosomes are secreted by most cell types and reflect the internal state of their cells of origin, playing crucial roles in the progression of various pathological conditions. Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial-like tissue outside the uterus, including in the ovaries, fallopian tubes, and peritoneal cavity. It primarily affects women of reproductive age and is often associated with infertility.
View Article and Find Full Text PDFRegulated release of small extracellular vesicles directs neutrophil recruitment in cutaneous wound healing.
J Invest Dermatol
September 2025
Department of Surgery, University of California San Diego, La Jolla, CA, United States; Department of Dermatology, University of California San Diego, La Jolla, CA, United States. Electronic address:
Normal cutaneous wound healing is a multicellular process that involves the release of small extracellular vesicles (sEVs) that coordinate intercellular communication by delivery of sEV payloads to recipient cells. We have recently shown how the pro-reparative activity of inflammatory cell sEVs, especially macrophage and neutrophil-derived sEVs, in the wound bed is dysregulated in impaired wound healing. Here we show that loss of Rab27A, a small GTPase that has a regulatory function in sEV secretion, reduces the release of neutrophil and macrophage-derived sEVs.
View Article and Find Full Text PDFA comprehensive insight into NETosis-extracellular vesicle crosstalk in autoimmune diseases.
Naunyn Schmiedebergs Arch Pharmacol
September 2025
Department of Medical Engineering, Al-Nisour University College, Baghdad, Iraq.
Neutrophils are granular and polymorphonuclear cells and one of the main participants of the innate immune system, which have received considerable attention due to the discovery of neutrophil extracellular traps (NETs). Extracellular vesicles (EVs), particularly those released by immune cells such as neutrophils, have been associated with the immunopathogenesis of autoimmune diseases. Besides, studies have reported a fundamental correlation between EVs and NETosis in autoimmune diseases.
View Article and Find Full Text PDFBiomarkers for the Diagnosis of Perinatal Mood and Anxiety Disorders: Existing Landscapes and Emerging Frontiers.
Biol Psychiatry
September 2025
Department of Psychiatry, University of Iowa, Iowa City, IA 52242; Iowa Neurosciences Institute, University of Iowa, Iowa City, IA 52242; Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242. Electronic address:
Perinatal mood and anxiety disorders (PMADs) are a spectrum of mental health conditions that are the most common pregnancy-related complications in the United States. Despite great strides in developing appropriate pharmacological and psychological treatments, PMADs continue to lack biological measures for diagnosis and prediction. Such measures could be effectively utilized to subtype and mechanistically explore PMADs and appropriately leverage mental healthcare resources.
View Article and Find Full Text PDFExtracellular vesicle signature is associated with cardio-metabolic improvement after bariatric surgery.
Eur J Prev Cardiol
September 2025
Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland.
Aims: Bariatric surgery (BS) reduces obesity-associated systemic inflammation leading to multiple cardiovascular (CV) and metabolic benefits. Here, we tested whether measuring vaso-inflammatory cytokines, gut hormones, and circulating extracellular vesicles (EV) provide vaso-inflammatory-metabolic signatures that better correlate to CV-metabolic outcomes after BS, compared to a standard clinical assessment including body weight (BW) loss and traditional CV risk factors.
Methods: In 111 patients with severe obesity, conventional clinical-biochemical parameters and non-conventional vaso-inflammatory-metabolic markers were analyzed at baseline, after 1- (T12) and 3-years (T36) post-BS and were associated to post-surgical BW loss and improvement of patients' CV-metabolic profile.