A Clinician's Guide to Understanding Bias in Critical Clinical Prediction Models.

Crit Care Clin

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC, USA; Department of Biostatistics and Bioinformatics, Duke University, Division of Translational Biomedical Informatics, Durham, NC, USA. Electronic address:

Published: October 2024


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Article Abstract

This narrative review focuses on the role of clinical prediction models in supporting informed decision-making in critical care, emphasizing their 2 forms: traditional scores and artificial intelligence (AI)-based models. Acknowledging the potential for both types to embed biases, the authors underscore the importance of critical appraisal to increase our trust in models. The authors outline recommendations and critical care examples to manage risk of bias in AI models. The authors advocate for enhanced interdisciplinary training for clinicians, who are encouraged to explore various resources (books, journals, news Web sites, and social media) and events (Datathons) to deepen their understanding of risk of bias.

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http://dx.doi.org/10.1016/j.ccc.2024.05.011DOI Listing

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