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http://dx.doi.org/10.1165/rcmb.2023-0268LE | DOI Listing |
Genes Dis
November 2025
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Oral squamous cell carcinoma in the background of/with oral submucous fibrosis (OSCC-OSF) has a unique etiology and is clinically distinct from other OSCCs. We previously identified ADAMTS9-AS2 as a functional tumor suppressor in OSCC-OSF through the regulation of PI3K-AKT signaling. However, its role in metabolic modulation and the underlying mechanisms remain unclear.
View Article and Find Full Text PDFBlood Adv
September 2025
Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Ex vivo platelet (PLT) production from induced pluripotent stem cells (iPSCs) represents a potential solution to address the limitations of donor-dependent PLT transfusion therapy. Although our established immortalized megakaryocyte progenitor cell lines (imMKCLs) from iPSCs enable large-scale production of functional iPSC-derived PLT products, cellular heterogeneity and senescence remain significant challenges for robust industrial-scale manufacturing. We recently identified RAS-like proto-oncogene B as a key regulator of immune properties and PLT productivity of imMKCLs, acting downstream of the let-7a-5p microRNA.
View Article and Find Full Text PDFStem Cell Res Ther
June 2025
Department of Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China.
Background: Osteoarthritis (OA) is a prevalent degenerative joint disorder affecting over 240 million people worldwide, yet no disease-modifying therapies currently exist, with clinical management limited to symptomatic relief or joint replacement. Exosomes (Exos) from bone marrow mesenchymal stem cells (Exo) play positive role in the treatment of cartilage damage. Parathyroid hormone (PTH) (1-34) can enhance cartilage repair.
View Article and Find Full Text PDFStem Cell Res Ther
June 2025
Xu Rongxiang Regenerative Medicine Research Center, School of Basic Medicine, Binzhou Medical University, Yantai, P.R. China.
Background: One major factor contributing to infertility in women of childbearing age is premature ovarian insufficiency (POI). Exosomes produced from human umbilical cord mesenchymal stem cells (hUMSC-Exos) have drawn a lot of attention lately as a potential treatment for ovarian dysfunction brought on by POI. However, its therapeutic mechanism is still unclear and needs further exploration.
View Article and Find Full Text PDFInt J Biol Macromol
June 2025
Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address:
ASAP1 (Ankyrin Repeat and PH Domain 1) is a macromolecular regulatory protein, which has been shown to play an important role in a variety of tumors in recent years. Gastric cancer (GC), as a highly lethal malignancy worldwide, is in urgent need of new biomarkers and therapeutic targets. Tissue samples from multiple gastric cancer patients were collected and analyzed through TCGA and GEO databases.
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