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The article presents a semi-automatic approach to generating structured hexahedral meshes of patient-specific aortas ailed by aortic dissection. The condition manifests itself as a formation of two blood flow channels in the aorta, as a result of a tear in the inner layers of the aortic wall. Subsequently, the morphology of the aorta is greatly impacted, making the task of domain discretization highly challenging. The meshing algorithm presented herein is automatic for the individual lumina, whereas the tears require user interaction. Starting from an input (triangle) surface mesh, we construct an implicit surface representation as well as a topological skeleton, which provides a basis for the generation of a block-structure. Thereafter, the mesh generation is performed via transfinite maps. The meshes are structured and fully hexahedral, exhibit good quality and reliably match the original surface. As they are generated with computational fluid dynamics in mind, a fluid flow simulation is performed to verify their usefulness. Moreover, since the approach is based on valid block-structures, the meshes can be made very coarse (around 1000 elements for an entire aortic dissection domain), and thus promote using solvers based on the geometric multigrid method, which is typically reliant on the presence of a hierarchy of coarser meshes.
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http://dx.doi.org/10.1002/cnm.3860 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Department of Gastroenterology and Hepatology, University of Balamand, Beirut, Lebanon.
Unlabelled: Aortic dissection is a life-threatening cardiovascular emergency, particularly Stanford type A, which typically necessitates urgent surgical intervention. Despite advances in surgical techniques and perioperative care, preoperative bleeding and coagulopathy remain significant challenges. Tranexamic acid, an antifibrinolytic agent, is widely used to minimize perioperative bleeding in cardiovascular surgeries; however, its role in the non-surgical, preoperative stabilization of aortic dissection has not been well established.
View Article and Find Full Text PDFRev Cardiovasc Med
August 2025
Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Background: Coagulation disorders are potentially one of the most important pathogeneses of acute respiratory distress syndrome (ARDS) following acute type A aortic dissection (ATAAD). This study aimed to determine whether aortic dissection singularly and cardiopulmonary bypass (CPB) surgery can activate coagulation pathways, promoting ARDS development in patients with ATAAD.
Methods: A total of 450 patients who received treatment at Beijing Anzhen Hospital, Capital Medical University, between March 2023 and February 2024 were consecutively enrolled in this prospective cohort study.
J Biomech
September 2025
Division of Vascular Surgery, Stanford University, Stanford, 94305, CA, USA.
The helical morphology of Type B aortic dissections (TBAD) represents a potentially important geometric biomarker that may influence dissection progression. While three-dimensional surface-based quantification methods provide accurate TBAD helicity assessment, their clinical adoption remains limited by significant processing time. We developed and validated a clinically practical centerline-based helicity quantification method using routine imaging software (TeraRecon) against an extensively validated surface-based method (SimVascular).
View Article and Find Full Text PDFFuture Cardiol
September 2025
Department of Surgery, Harlem Hospital Center, New York, NY, USA.
Introduction: The aim of this article is to compare the long-term efficacy of Thoracic Endovascular Aortic Repair (TEVAR) versus Optimal Medical Therapy (OMT) in reducing mortality among adult patients with uncomplicated Stanford type B aortic dissection (uSTBAD).
Methods: An electronic search of PubMed, Cochrane Central and Google Scholar was conducted for studies comparing TEVAR with OMT for mortality in adult patients with uSTBAD. Relevant outcomes, including mortality, aortic rupture, re-intervention, retrograde type A dissection, myocardial infarction and stroke were analyzed and presented as risk ratios (RRs) along with their 95% confidence intervals (95% CI).
JTCVS Open
August 2025
Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa.
Objective: Valve selection in acute type A aortic dissection (ATAAD) requiring aortic root replacement is challenging given the clinical acuity, unknown patient preferences, risk of surgical bleeding, and limited life expectancy. We sought to identify long-term outcomes of mechanical versus bioprosthetic aortic root replacement in young patients with ATAAD.
Methods: Retrospective review of our institution's database of ATAAD was conducted to identify patients aged 65 years and younger who underwent mechanical Bentall (mech-Bentall) or bioprosthetic Bentall (bio-Bentall) for ATAAD from 2002 to 2022.