Rapid diagnosis of a fox's death case using nanopore sequencing reveals the infection with an Artic-like rabies virus.

Virol Sin

Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China. Electronic address:

Published: October 2024


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

• We detected a rabies virus (RABV) in a fox's death case within 6 h upon sample receipt using nanopore direct sequencing. • The virus belongs to AL2 sub-lineage, suggesting a high risk of fox-related AL2 RABV on the northeastern border of China. • Nanopore sequencing showed less sensitivity and accuracy, though it helped us rapidly identify the cause of death.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738774PMC
http://dx.doi.org/10.1016/j.virs.2024.08.010DOI Listing

Publication Analysis

Top Keywords

fox's death
8
death case
8
nanopore sequencing
8
rabies virus
8
rapid diagnosis
4
diagnosis fox's
4
case nanopore
4
sequencing reveals
4
reveals infection
4
infection artic-like
4

Similar Publications

Background: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital with COVID-19.

Methods: Patients admitted with COVID-19 pneumonia to 107 UK hospitals were randomly assigned (1:1) to either usual care alone or usual care plus a single 1 g infusion of sotrovimab, using web-based unstratified randomisation.

View Article and Find Full Text PDF

Mutations in BRCA1 and BRCA2 genes are the leading cause of hereditary breast and ovarian cancer. BRCA1/2-mutant cells are defective in repairing damaged DNA by homologous recombination and are characterized by hypersensitivity to PARP inhibitors. PARP inhibitors can trap PARP proteins on the chromatin, a mechanism that can contribute to the death of BRCA1/2-deficient cells.

View Article and Find Full Text PDF

Background: Molnupiravir and nirmatrelvir-ritonavir are oral antivirals that have shown efficacy in preventing disease progression in outpatients with COVID-19. We aimed to evaluate these treatments for patients hospitalised with COVID-19 pneumonia, for whom data on these antivirals are scarce.

Methods: The RECOVERY trial is a randomised, controlled, open-label, adaptive platform trial testing treatments for COVID-19.

View Article and Find Full Text PDF

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by four-repeat (4R) tau protein deposition. The substantia nigra (SN) and midbrain tegmentum nuclei (MBT) are consistently affected. Lymphocyte infiltrates are scarce in the brains of patients with neurodegenerative diseases, although a few reports have described their presence in the α-synucleinopathy Parkinson's disease (PD).

View Article and Find Full Text PDF

Background: Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients.

View Article and Find Full Text PDF